TLR3

Gene Symbol	TLR3
Entrez Gene	7098
Alt Symbol	CD283, IIAE2
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 3
Other Description	-
Swissprots	Q4VAL2 E9PGH4 E6Y0F1 Q504W0 E6Y0F0 B2RAI7 O15455 B7Z7K0
Accessions	ABC86908 ABC86909 ABC86910 CAL68868 CAT16976 EAX04628 EAX04629 O15455 AB445631 BAG55028 AK302143 BAH13636 AK314208 BAG36884 BC017954 BC043204 BC059372 AAH59372 BC068487 BC094737 AAH94737 BC096333 AAH96333 BC096334 AAH96334 BC096335 AAH96335 BU624267 DA374150 DQ445682 ABE01399 DQ470075 ABF06633 DQ470076 ABF06634 DQ470077 ABF06635 DQ470078 ABF06636 DQ470079 ABF06637 U88879 AAC34134 NM_003265 NP_003256
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
Tissue Specificity	Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}.
Top Pathways	Toll-like receptor signaling pathway, Hepatitis C, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TLR3 (CD283) Human ELISA Kit - ab131557 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Human TLR3 ELISA Kit (Sandwich ELISA) - LS-F5810 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 156-10000 pg/ml

Mouse TLR3 ELISA Kit (Sandwich ELISA) - LS-F8377 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 23.64 pg/ml Range 156-10000 pg/ml

Human TLR3 ELISA Kit (Sandwich ELISA) - LS-F2750 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Human TLR3 ELISA Kit (Sandwich ELISA) - LS-F12775 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 156-10000 pg/ml

Human TLR3 DuoSet ELISA - DY1487-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 93.80 - 6,000 pg/mL

Human TLR3 ELISA Kit - 55R-1792 from Fitzgerald Category ELISA Kit Prices $460.00 Sizes 1 kit

Human CD283 ELISA Kit - abx056095 from Abbexa Category ELISA Kit

TLR3, Human, ELISA Kit - PB-0907 from ARP American Research Products Category ELISA Kit Prices $449.00 Sizes 96 t Sensitivity < 10 pg/ml Range 156pg/ml-10,000pg/ml

Toll Like Receptor 3 (TLR3), Human, ELISA Kit - SEB989Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 28pg/mL Range 78-5,000pg/mL

Toll-like receptor 3, TLR-3, Human, ELISA Kit - CSB-E14014h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Toll-like receptor 3, TLR3, Human, ELISA Kit - E1989h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Custom Human TLR3 ELISA - ELH-TLR3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

TLR3 (Human) ELISA Kit - DEIA4320 from Creative Diagnostics Category ELISA Kit Range 156pg/mL-10,000 pg/mL

CD283, ELISA Kit - MBS824720 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 156 pg/ml - 10000 pg/ml

TLR3, ELISA Kit - MBS175785 from MyBioSource Category ELISA Kit Prices $455.00 Sizes 1x96 wells Sensitivity <10pg/ml Range 156pg/ml-10000pg/ml

Toll Like Receptor 3, ELISA Kit - MBS015910 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS011820 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS100937 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS021585 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS023134 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

Toll Like Receptor 3, ELISA Kit - MBS087141 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS053349 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS046448 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 3, ELISA Kit - MBS031859 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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