TLR3
| Gene Symbol | TLR3 |
|---|---|
| Entrez Gene | 7098 |
| Alt Symbol | CD283, IIAE2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-like receptor 3 |
| Other Description | - |
| Swissprots | Q4VAL2 E9PGH4 E6Y0F1 Q504W0 E6Y0F0 B2RAI7 O15455 B7Z7K0 |
| Accessions | ABC86908 ABC86909 ABC86910 CAL68868 CAT16976 EAX04628 EAX04629 O15455 AB445631 BAG55028 AK302143 BAH13636 AK314208 BAG36884 BC017954 BC043204 BC059372 AAH59372 BC068487 BC094737 AAH94737 BC096333 AAH96333 BC096334 AAH96334 BC096335 AAH96335 BU624267 DA374150 DQ445682 ABE01399 DQ470075 ABF06633 DQ470076 ABF06634 DQ470077 ABF06635 DQ470078 ABF06636 DQ470079 ABF06637 U88879 AAC34134 NM_003265 NP_003256 |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. |
| Tissue Specificity | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}. |
| Top Pathways | Toll-like receptor signaling pathway, Hepatitis C, Influenza A, Herpes simplex infection |
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