TLR3

Gene Symbol	TLR3
Entrez Gene	7098
Alt Symbol	CD283, IIAE2
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 3
Other Description	-
Swissprots	Q4VAL2 E9PGH4 E6Y0F1 Q504W0 E6Y0F0 B2RAI7 O15455 B7Z7K0
Accessions	ABC86908 ABC86909 ABC86910 CAL68868 CAT16976 EAX04628 EAX04629 O15455 AB445631 BAG55028 AK302143 BAH13636 AK314208 BAG36884 BC017954 BC043204 BC059372 AAH59372 BC068487 BC094737 AAH94737 BC096333 AAH96333 BC096334 AAH96334 BC096335 AAH96335 BU624267 DA374150 DQ445682 ABE01399 DQ470075 ABF06633 DQ470076 ABF06634 DQ470077 ABF06635 DQ470078 ABF06636 DQ470079 ABF06637 U88879 AAC34134 NM_003265 NP_003256
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
Tissue Specificity	Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}.
Top Pathways	Toll-like receptor signaling pathway, Hepatitis C, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Toll-like Receptor 3 siRNA I - 6236 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

TLR3 CRISPR/Cas9 KO Plasmid (h) - sc-400512 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 HDR Plasmid (h) - sc-400512-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 Double Nickase Plasmid (h) - sc-400512-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 Double Nickase Plasmid (h2) - sc-400512-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 CRISPR Activation Plasmid (h) - sc-400512-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 CRISPR Activation Plasmid (h2) - sc-400512-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 Lentiviral Activation Particles (h) - sc-400512-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 Lentiviral Activation Particles (h2) - sc-400512-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLR3 siRNA (h) - sc-36685 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TLR3 shRNA Plasmid (h) - sc-36685-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TLR3 shRNA (h) Lentiviral Particles - sc-36685-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU019541 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21401 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21401 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02500 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02500

TLR3 siRNA (Human) - CRH4865 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TLR3 RNAi - H00007098-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TLR3 - MBS8205224 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TLR3 (NM_003265.2) - SHH427972 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TLR3(NM_003265.2) - SHL073070 from Creative biogene Category siRNA Species Reactivities Human

Human TLR3 siRNA - orb265367 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TLR3 shRNA Plasmid (Human) - CHH4865 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TLR3 miRNA 3'UTR clone - MiUTR1H-10435 from Creative biogene Species Reactivities Human

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