| Gene Symbol |
EIF4EBP1
|
| Entrez Gene |
1978
|
| Alt Symbol |
4E-BP1, 4EBP1, BP-1, PHAS-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4E binding protein 1
|
| Other Description |
eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
|
| Swissprots |
Q6IBN3 Q13541 B2R502 D3DSW8
|
| Accessions |
CCW44094 EAW63341 EAW63342 Q13541 AB044548 BAB18650 AK312011 BAG34949 BC004459 AAH04459 BC058073 AAH58073 BF964628 BT007162 AAP35826 CR456769 CAG33050 DQ890570 ABM92187 DQ893731 ABM84657 L36055 AAA62269 NM_004095 NP_004086
|
| Function |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:7935836}.
|
| Top Pathways |
RNA transport, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway
|
![Western Blot: eIF4EBP1 Overexpression Lysate (Adult Normal) [NBL1-10206] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eIF4EBP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7347_eIF4EBP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10206-img0002.jpg)