GPR75

Gene Symbol GPR75
Entrez Gene 10936
Alt Symbol GPRchr2, WI31133
Species Human
Gene Type protein-coding
Description G protein-coupled receptor 75
Other Description probable G-protein coupled receptor 75
Swissprots Q6NWR2 O95800 B2RC02
Accessions AAD22770 AAY15018 EAX00162 O95800 AF072693 AAD19849 AK314885 BAG37399 BC067475 AAH67475 BC067476 AAH67476 NM_006794 NP_006785
Function G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.
Subcellular Location Cell membrane; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level). {ECO:0000269|PubMed:10381362, ECO:0000269|PubMed:11466257, ECO:0000269|PubMed:23979485}.

GPR75 (H-75) - sc-382293 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GPR75 (S-14) - sc-164538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GPR75 (S-14): sc-164538. Western blot analysis of GPR75 expression in COLO 205 (A) and HeLa (B) whole cell lysates.

GPR75 (T-14) - sc-164539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GPR75 (T-14): sc-164539. Western blot analysis of GPR75 expression in SH-SY5Y whole cell lysate.

Anti-GPCR GPR75 antibody - ab75581 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR GPR75 antibody (ab75581) at 1/500 dilutionLane 1 : Extracts from HT-29 cellsLane 2 : Extracts from K562 cellsLane 3 : Extracts from HT-29 cells with Immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-GPCR GPR75 antibody - ab130666 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR75 antibody (ab130666) at 1/100 dilution + U937 cell lysate at 35 µg

Anti-GPR75 Antibody (aa396-425) - LS-C159774 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPR75 Antibody western blot of U937 cell line lysates (35 ug/lane). The GPR75 antibody detected the GPR75 protein (arrow).

Anti-GPR75 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1591 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody LS-A1591 IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR75 Antibody (C-Terminus) IHC-plus™ - LS-A1589 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody LS-A1589 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR75 Antibody (C-Terminus) IHC-plus™ - LS-A1594 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody LS-A1594 IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR75 Antibody (N-Terminus) IHC-plus™ - LS-A3250 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody LS-A3250 IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR75 Antibody (Extracellular Domain) IHC-plus™ - LS-A1590 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A1590 concentration 3-7 ug/ml.

Anti-GPR75 Antibody (C-Terminus) IHC-plus™ - LS-A1593 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A1593 dilution 10-25 ug/ml.

Anti-GPR75 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A3259 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A3259 dilution 18 ug/ml.

Anti-GPR75 Antibody (C-Terminus) IHC-plus™ - LS-A3252 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR75 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A3252 dilution 4-7 ug/ml.

Anti-GPR75 Antibody (C-Terminus) - LS-C109745 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPR75 antibody LS-C109745 Western blot of COLO205 cell lysate.

Anti-GPR75 Antibody (clone 11n81) - LS-C184771 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n81

Anti-GPR75 Antibody (aa468-517) - LS-C109744 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPR75 antibody LS-C109744 Western blot of HepG2 cell lysate.

Anti-GPR75 Antibody (aa396-425, APC) - LS-C222658 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa396-425, AP) - LS-C222657 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa396-425, Biotin) - LS-C222659 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa381-430) - LS-C120723 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using GPR75 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-GPR75 Antibody (aa396-425, Azide-free, HRP) - LS-C222661 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa396-425, FITC) - LS-C222660 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa423-468) - LS-C313791 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR75 Antibody (aa396-425, PE) - LS-C222662 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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