| Gene Symbol |
GPR75
|
| Entrez Gene |
10936
|
| Alt Symbol |
GPRchr2, WI31133
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 75
|
| Other Description |
probable G-protein coupled receptor 75
|
| Swissprots |
Q6NWR2 O95800 B2RC02
|
| Accessions |
AAD22770 AAY15018 EAX00162 O95800 AF072693 AAD19849 AK314885 BAG37399 BC067475 AAH67475 BC067476 AAH67476 NM_006794 NP_006785
|
| Function |
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level). {ECO:0000269|PubMed:10381362, ECO:0000269|PubMed:11466257, ECO:0000269|PubMed:23979485}.
|