GPR75

Gene Symbol	GPR75
Entrez Gene	10936
Alt Symbol	GPRchr2, WI31133
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor 75
Other Description	probable G-protein coupled receptor 75
Swissprots	Q6NWR2 O95800 B2RC02
Accessions	AAD22770 AAY15018 EAX00162 O95800 AF072693 AAD19849 AK314885 BAG37399 BC067475 AAH67475 BC067476 AAH67476 NM_006794 NP_006785
Function	G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.
Subcellular Location	Cell membrane; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level). {ECO:0000269|PubMed:10381362, ECO:0000269|PubMed:11466257, ECO:0000269|PubMed:23979485}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPR75 Gene cDNA Clone - orb143447 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

Human-GPR75-cDNA-Clone - DC08609 from Abgent, a WuXi AppTec company Prices $729.00 Sizes 10 µg Species Human Accession BC067475

Human GPR75 (NP_006785) VersaClone cDNA - RDC0141 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

Mouse GPR75 (NP_780699) VersaClone cDNA - RDC0845 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

GPR75 - MBS1276131 from MyBioSource Species Human Accession BC067475

Human GPR75 ORF Clone(NM_006794.3) - CDCL165250 from Creative Biomart Species Human Accession NM_006794.3

Human GPR75 Gene ORF cDNA clone in cloning vector - HG13831-G from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, N-His tag - HG13831-NH from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13831-CY from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid - HG13831-UT from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-His tag - HG13831-CH from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13831-NY from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13831-NF from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13831-ACG from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13831-NM from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13831-CF from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13831-CM from Sino Biological Species Human

Human GPR75 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13831-ACR from Sino Biological Species Human

Human GPR75 ORF Clone (BC067475) - CDCS412917 from Creative biogene Species Human Accession O95800

Human GPR75 ORF clone (BC067475) - CDCB159666 from Creative biogene Species Human

Search more