GPR75

Gene Symbol GPR75
Entrez Gene 10936
Alt Symbol GPRchr2, WI31133
Species Human
Gene Type protein-coding
Description G protein-coupled receptor 75
Other Description probable G-protein coupled receptor 75
Swissprots Q6NWR2 O95800 B2RC02
Accessions AAD22770 AAY15018 EAX00162 O95800 AF072693 AAD19849 AK314885 BAG37399 BC067475 AAH67475 BC067476 AAH67476 NM_006794 NP_006785
Function G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.
Subcellular Location Cell membrane; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level). {ECO:0000269|PubMed:10381362, ECO:0000269|PubMed:11466257, ECO:0000269|PubMed:23979485}.

GPR75 CRISPR/Cas9 KO Plasmid (h) - sc-406566 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 HDR Plasmid (h) - sc-406566-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 Double Nickase Plasmid (h) - sc-406566-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 Double Nickase Plasmid (h2) - sc-406566-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 CRISPR Activation Plasmid (h) - sc-406566-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 CRISPR Activation Plasmid (h2) - sc-406566-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 Lentiviral Activation Particles (h) - sc-406566-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 Lentiviral Activation Particles (h2) - sc-406566-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 siRNA (h) - sc-94341 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR75 shRNA Plasmid (h) - sc-94341-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR75 shRNA (h) Lentiviral Particles - sc-94341-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR75 RNAi - H00010936-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU121351 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9615 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9615 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GPR75 siRNA (Human) - CRH7459 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR75 - MBS8223171 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR75 CRISPR/Cas9 KO Plasmid (h2) - sc-406566-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR75 HDR Plasmid (h2) - sc-406566-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human GPR75 (NM_006794.3) - SHH307010 from Creative biogene

Category siRNA
Species Reactivities Human

Human GPR75 siRNA - orb267961 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR75 shRNA Plasmid (Human) - CHH7459 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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