NEIL1

Gene Symbol NEIL1
Entrez Gene 79661
Alt Symbol FPG1, NEI1, hFPG1
Species Human
Gene Type protein-coding
Description nei endonuclease VIII-like 1 (E. coli)
Other Description DNA glycosylase/AP lyase Neil1|DNA-(apurinic or apyrimidinic site) lyase Neil1|NEH1|endonuclease 8-like 1|endonuclease VIII|endonuclease VIII-like 1|nei homolog 1|nei-like protein 1
Swissprots Q96FI4 Q6ZRA7 Q86XW7 Q9H6C3 D3DW75
Accessions AAO74826 EAW99255 EAW99256 EAW99257 EAW99258 EAW99259 EAW99260 Q96FI4 AB079068 BAC06476 AK026055 BAB15337 AK026216 AK097008 AK128372 BC010876 AAH10876 DB282730 DQ891430 ABM82356 DQ894605 ABM85531 XM_005254659 XP_005254716 XM_006720677 XP_006720740 XM_006720678 XP_006720741 XM_006720679 XP_006720742 XM_006720680 XP_006720743 XM_006720681 XP_006720744 XM_011522001 XP_011520303 XM_011522002 XP_011520304 XM_011522003 XP_011520305 XM_011522004 XP_011520306 XM_011522005 XP_011520307 XM_011522006 XP_011520308 XM_011522007 XP_011520309 XM_011522008 XP_011520310 XR_243127 XR_429472 NM_001256552 NP_001243481 NM_024608 NP_078884 NR_046311
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:11904416}.
Top Pathways Base excision repair

Human NEIL1 ELISA Kit (Sandwich ELISA) - LS-F7608 from LifeSpan Bioscience

Category ELISA Kit
Prices $790.00
Sizes 1 plate
Sensitivity 0.062 ng/ml
Range 0.156-10 ng/ml

Human NEIL1 ELISA Kit - abx152469 from Abbexa

Category ELISA Kit
Sensitivity 0.062 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Nei Endonuclease VIII Like Protein 1 (NEIL1), Human, ELISA Kit - SEL915Hu from ARP American Research Products

Category ELISA Kit
Prices $790.00
Sizes 96 t
Sensitivity 0.054ng/mL
Range 0.156-10ng/mL

NEIL1 (Human) Matched Antibody Pair - H00079661-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS073728 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS087561 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS083988 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS087062 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS106528 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS072511 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS066373 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS057160 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS089943 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS076894 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS063594 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS084331 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS091787 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS065163 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS048806 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS080055 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS073147 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS048321 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS086981 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS080085 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nei Endonuclease VIII Like Protein 1, ELISA Kit - MBS099052 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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