NEIL1

Gene Symbol	NEIL1
Entrez Gene	79661
Alt Symbol	FPG1, NEI1, hFPG1
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 1 (E. coli)
Other Description	DNA glycosylase/AP lyase Neil1|DNA-(apurinic or apyrimidinic site) lyase Neil1|NEH1|endonuclease 8-like 1|endonuclease VIII|endonuclease VIII-like 1|nei homolog 1|nei-like protein 1
Swissprots	Q96FI4 Q6ZRA7 Q86XW7 Q9H6C3 D3DW75
Accessions	AAO74826 EAW99255 EAW99256 EAW99257 EAW99258 EAW99259 EAW99260 Q96FI4 AB079068 BAC06476 AK026055 BAB15337 AK026216 AK097008 AK128372 BC010876 AAH10876 DB282730 DQ891430 ABM82356 DQ894605 ABM85531 XM_005254659 XP_005254716 XM_006720677 XP_006720740 XM_006720678 XP_006720741 XM_006720679 XP_006720742 XM_006720680 XP_006720743 XM_006720681 XP_006720744 XM_011522001 XP_011520303 XM_011522002 XP_011520304 XM_011522003 XP_011520305 XM_011522004 XP_011520306 XM_011522005 XP_011520307 XM_011522006 XP_011520308 XM_011522007 XP_011520309 XM_011522008 XP_011520310 XR_243127 XR_429472 NM_001256552 NP_001243481 NM_024608 NP_078884 NR_046311
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11904416}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NEIL1 full length protein - ab123204 from Abcam Category Protein Source E. coli Species Human

NEIL1 Antibody Blocking Peptide - LS-E25500 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEIL1 Antibody Blocking Peptide - LS-E23281 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEIL1 Antibody Blocking Peptide - LS-E10265 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEIL1 Recombinant Protein - H00079661-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NEIL1 Partial Recombinant Protein - H00079661-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human NEIL1 Protein - NBP1-78846 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E.coli Species Human

NEIL1-Antibody-Center-Blocking-Peptide - BP9696c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NEIL1 blocking peptide - GTX89756-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human NEIL1 protein (His Tag) - orb139387 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human NEIL1 protein - orb244912 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human NEIL1 protein - orb168917 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

NEIL1 Immunizing peptide - orb17750 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

NEIL1 protein (His tag) - 80R-2089 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

NEIL1 Peptide - AC21-0329-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NEIL1 (1-390, His-tag) - AR50172PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

NEIL1 (1-390, His-tag) - AR50172PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

NEIL1 - H00079661-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NEIL1 - H00079661-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NEIL1 - H00079661-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

NEIL1 - H00079661-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

NEIL1 - H00079661-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

NEIL1, 1-390aa, Human, His tag E.coli - 01-P1347 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

NEIL1 Peptide - 45-942P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

NEIL1 fusion protein - Ag8307 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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