| Gene Symbol |
NEIL1
|
| Entrez Gene |
79661
|
| Alt Symbol |
FPG1, NEI1, hFPG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nei endonuclease VIII-like 1 (E. coli)
|
| Other Description |
DNA glycosylase/AP lyase Neil1|DNA-(apurinic or apyrimidinic site) lyase Neil1|NEH1|endonuclease 8-like 1|endonuclease VIII|endonuclease VIII-like 1|nei homolog 1|nei-like protein 1
|
| Swissprots |
Q96FI4 Q6ZRA7 Q86XW7 Q9H6C3 D3DW75
|
| Accessions |
AAO74826 EAW99255 EAW99256 EAW99257 EAW99258 EAW99259 EAW99260 Q96FI4 AB079068 BAC06476 AK026055 BAB15337 AK026216 AK097008 AK128372 BC010876 AAH10876 DB282730 DQ891430 ABM82356 DQ894605 ABM85531 XM_005254659 XP_005254716 XM_006720677 XP_006720740 XM_006720678 XP_006720741 XM_006720679 XP_006720742 XM_006720680 XP_006720743 XM_006720681 XP_006720744 XM_011522001 XP_011520303 XM_011522002 XP_011520304 XM_011522003 XP_011520305 XM_011522004 XP_011520306 XM_011522005 XP_011520307 XM_011522006 XP_011520308 XM_011522007 XP_011520309 XM_011522008 XP_011520310 XR_243127 XR_429472 NM_001256552 NP_001243481 NM_024608 NP_078884 NR_046311
|
| Function |
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11904416}.
|
| Top Pathways |
Base excision repair
|