| Gene Symbol |
ESRP1
|
| Entrez Gene |
54845
|
| Alt Symbol |
RBM35A, RMB35A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epithelial splicing regulatory protein 1
|
| Other Description |
RNA binding motif protein 35A|RNA-binding motif protein 35A|RNA-binding protein 35A
|
| Swissprots |
Q499G3 A8MPX1 Q9NXL8 E9PB47 A6NHA8 Q2M2B0 Q6PJ86 Q6NXG1
|
| Accessions |
EAW91720 EAW91721 Q6NXG1 AI990751 AK000178 BAA90992 AK001805 BC019932 AAH19932 BC035406 BC052574 BC067098 AAH67098 BC099916 AAH99916 BC101621 BC112043 AAI12044 BG182742 BG212336 BX641160 BX647570 XM_005250991 XP_005251048 XM_005250992 XP_005251049 XR_242393 NM_001034915 NP_001030087 NM_001122825 NP_001116297 NM_001122826 NP_001116298 NM_001122827 NP_001116299 NM_017697 NP_060167
|
| Function |
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19285943}.
|
| Tissue Specificity |
Epithelial cell-specific. {ECO:0000269|PubMed:19285943}.
|