| Gene Symbol | ESRP1 |
|---|---|
| Entrez Gene | 54845 |
| Alt Symbol | RBM35A, RMB35A |
| Species | Human |
| Gene Type | protein-coding |
| Description | epithelial splicing regulatory protein 1 |
| Other Description | RNA binding motif protein 35A|RNA-binding motif protein 35A|RNA-binding protein 35A |
| Swissprots | Q499G3 A8MPX1 Q9NXL8 E9PB47 A6NHA8 Q2M2B0 Q6PJ86 Q6NXG1 |
| Accessions | EAW91720 EAW91721 Q6NXG1 AI990751 AK000178 BAA90992 AK001805 BC019932 AAH19932 BC035406 BC052574 BC067098 AAH67098 BC099916 AAH99916 BC101621 BC112043 AAI12044 BG182742 BG212336 BX641160 BX647570 XM_005250991 XP_005251048 XM_005250992 XP_005251049 XR_242393 NM_001034915 NP_001030087 NM_001122825 NP_001116297 NM_001122826 NP_001116298 NM_001122827 NP_001116299 NM_017697 NP_060167 |
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19285943}. |
| Tissue Specificity | Epithelial cell-specific. {ECO:0000269|PubMed:19285943}. |