Gene Symbol | ESRP1 |
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Entrez Gene | 54845 |
Alt Symbol | RBM35A, RMB35A |
Species | Human |
Gene Type | protein-coding |
Description | epithelial splicing regulatory protein 1 |
Other Description | RNA binding motif protein 35A|RNA-binding motif protein 35A|RNA-binding protein 35A |
Swissprots | Q499G3 A8MPX1 Q9NXL8 E9PB47 A6NHA8 Q2M2B0 Q6PJ86 Q6NXG1 |
Accessions | EAW91720 EAW91721 Q6NXG1 AI990751 AK000178 BAA90992 AK001805 BC019932 AAH19932 BC035406 BC052574 BC067098 AAH67098 BC099916 AAH99916 BC101621 BC112043 AAI12044 BG182742 BG212336 BX641160 BX647570 XM_005250991 XP_005251048 XM_005250992 XP_005251049 XR_242393 NM_001034915 NP_001030087 NM_001122825 NP_001116297 NM_001122826 NP_001116298 NM_001122827 NP_001116299 NM_017697 NP_060167 |
Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19285943}. |
Tissue Specificity | Epithelial cell-specific. {ECO:0000269|PubMed:19285943}. |
RBM35A CRISPR/Cas9 KO Plasmid (h) - sc-405645 from Santa Cruz Biotechnology
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RBM35A HDR Plasmid (h) - sc-405645-HDR from Santa Cruz Biotechnology
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RBM35A Double Nickase Plasmid (h) - sc-405645-NIC from Santa Cruz Biotechnology
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RBM35A Double Nickase Plasmid (h2) - sc-405645-NIC-2 from Santa Cruz Biotechnology
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RBM35A CRISPR Activation Plasmid (h) - sc-405645-ACT from Santa Cruz Biotechnology
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RBM35A CRISPR Activation Plasmid (h2) - sc-405645-ACT-2 from Santa Cruz Biotechnology
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RBM35A Lentiviral Activation Particles (h) - sc-405645-LAC from Santa Cruz Biotechnology
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RBM35A Lentiviral Activation Particles (h2) - sc-405645-LAC-2 from Santa Cruz Biotechnology
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RBM35A siRNA (h) - sc-77526 from Santa Cruz Biotechnology
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RBM35A shRNA Plasmid (h) - sc-77526-SH from Santa Cruz Biotechnology
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RBM35A shRNA (h) Lentiviral Particles - sc-77526-V from Santa Cruz Biotechnology
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ESRP1 RNAi - H00054845-R02 from Novus Biologicals
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ESRP1 RNAi - H00054845-R01 from Novus Biologicals
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MISSION® esiRNA - EHU073661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7992 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7992 from Sigma-Aldrich
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ESRP1 siRNA (Human) - CRJ0260 from Cohesion Biosciences
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ESRP1 - MBS8233943 from MyBioSource
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shRNA set against Human ESRP1 (NM_017697.3) - SHH287425 from Creative biogene
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ESRP1 shRNA Plasmid (Human) - CHJ0260 from Cohesion Biosciences
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ESRP1 miRNA 3'UTR clone - MiUTR3H-12699 from Creative biogene
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ESRP1 miRNA 3'UTR clone - MiUTR3H-12700 from Creative biogene
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ESRP1 miRNA 3'UTR clone - MiUTR3H-12701 from Creative biogene
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ESRP1 miRNA 3'UTR clone - MiUTR3H-12702 from Creative biogene
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ESRP1 miRNA 3'UTR clone - MiUTR3H-12703 from Creative biogene
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