| Gene Symbol |
ADAMTS5
|
| Entrez Gene |
11096
|
| Alt Symbol |
ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase with thrombospondin type 1 motif, 5
|
| Other Description |
A disintegrin and metalloproteinase with thrombospondin motifs 5|a disintegrin and metalloproteinase with thrombospondin motifs 11|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)|aggrecanase-2
|
| Swissprots |
Q9UKP2 Q9UNA0 Q52LV4
|
| Accessions |
BAA95503 BAA95504 EAX09948 EAX09949 Q9UNA0 AF086299 AF086358 AF141293 AAF02493 AF142099 AAD49577 AK094057 AK095905 BC093775 AAH93775 BC093777 AAH93777 XM_011529448 XP_011527750 NM_007038 NP_008969
|
| Function |
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
|
![Western Blot: ADAMTS5 Overexpression Lysate (Adult Normal) [NBL1-07317] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ADAMTS5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10041_ADAMTS5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07317-img0002.jpg)