ADAMTS5

Gene Symbol ADAMTS5
Entrez Gene 11096
Alt Symbol ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2
Species Human
Gene Type protein-coding
Description ADAM metallopeptidase with thrombospondin type 1 motif, 5
Other Description A disintegrin and metalloproteinase with thrombospondin motifs 5|a disintegrin and metalloproteinase with thrombospondin motifs 11|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)|aggrecanase-2
Swissprots Q9UKP2 Q9UNA0 Q52LV4
Accessions BAA95503 BAA95504 EAX09948 EAX09949 Q9UNA0 AF086299 AF086358 AF141293 AAF02493 AF142099 AAD49577 AK094057 AK095905 BC093775 AAH93775 BC093777 AAH93777 XM_011529448 XP_011527750 NM_007038 NP_008969
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.

ADAMTS-5 (D-16) - sc-83186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ADAMTS-5 (D-16): sc-83186. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing Z discs and cytoplasmic staining of myocytes.

ADAMTS-5 (H-200) - sc-134952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ADAMTS-5 (H-200): sc-134952. Western blot analysis of ADAMTS-5 expression in U-937 whole cell lysate.

Anti-ADAMTS5 antibody - ab41037 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab41037 stained MG-63 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab41037 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-ADAMTS5 antibody - ab182795 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labeling ADAMTS5 with ab182795 at 1/10. Image on the right is treated with the synthetic peptide.

Anti-ADAMTS5 antibody - ab135656 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAMTS5 antibody (ab135656) at 1/50 dilution + Mouse muscle tissue lyssate at 35 µg

Anti-ADAMTS5 antibody - ab45042 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAMTS5 antibody (ab45042) at 1/1000 dilutionLane 1 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with SF) Lane 2 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with TPA) Lane 3 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with IL1-alpha) Lane 4 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with IL1-beta) Lane 5 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with TNF-alpha) Lane 6 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with RA)

Anti-ADAMTS5 antibody - ab39203 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 antibody - Carboxyterminal end - ab39202 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab39202 staining Human normal liver parenchym. Staining is localized to cytoplasma and secreted.Left panel: with primary antibody at 2 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-ADAMTS5 antibody - Catalytic domain - ab50749 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAMTS5 antibody - Catalytic domain (ab50749) at 1/1000 dilutionLane 1 : rH-ADAMTS-5 Catalytic Domain at 0.1 µgLane 2 : rH-ADAMTS-5 Catalytic Domain at 0.04 µgLane 3 : rH-ADAMTS-5 Catalytic Domain at 0.02 µg

Anti-ADAMTS5 Antibody (C-Terminus) - LS-C122608 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa262-622) - LS-C124925 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ADAMTS5 Antibody - LS-C124924 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ADAMTS5 Antibody (C-Terminus) - LS-C126609 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa772-787) - LS-C313505 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ADAMTS5 antibody. IHC(P): Rat Brain Tissue.

Anti-ADAMTS5 Antibody (C-Terminus) IHC-plus™ - LS-A7768 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ADAMTS5 antibody LS-A7768 IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ADAMTS5 Antibody (Metalloprotease Domain) IHC-plus™ - LS-A7761 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ADAMTS5 Antibody (aa26-54, AP) - LS-C250845 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa26-54, APC) - LS-C250846 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa26-54, Biotin) - LS-C250847 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa26-54, FITC) - LS-C250848 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa26-54, Azide-free, HRP) - LS-C250849 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (Internal, AP) - LS-C274879 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody - LS-C136825 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (aa26-54, PE) - LS-C250851 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS5 Antibody (Internal, APC) - LS-C274880 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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