MAP3K11

Gene Symbol MAP3K11
Entrez Gene 4296
Alt Symbol MEKK11, MLK-3, MLK3, PTK1, SPRK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 11
Other Description SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase
Swissprots Q59F06 Q53H00 B4DS76 Q16584 Q6P2G4
Accessions CAI94235 EAW74417 EAW74418 Q16584 AB209655 BAD92892 AK057256 BAG51893 AK090614 BAG52196 AK092015 AK222781 BAD96501 AK299609 BAG61538 AK315557 BAG37933 AK316032 BAH14403 AU119082 BC011263 AAH11263 BC064543 AAH64543 L32976 AAA59859 U07747 AAA19647 XR_428915 NM_002419 NP_002410
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
Tissue Specificity Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|PubMed:8195146}.
Top Pathways MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

MLK3 Antibody - 2817 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells using MLK3 Antibody.

MLK3 Antibody - 2812 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

MLK3 (A-20) - sc-15068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLK3 (A-20): sc-15068. Western blot analysis of MLK3 expression in rat cerebellum tissue extract.

MLK3 (B-12) - sc-166873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MLK3 (B-12): sc-166873. Western blot analysis of MLK3 expression in non-transfected: sc-110760 (A) and human MLK3 transfected: sc-111047 (B) 293 whole cell lysates.

MLK3 (C-20) - sc-536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MLK3 (C-20): sc-536. Western blot analysis of MLK3 expression in Hep G2 (A) and Jurkat (B) whole cell lysates.

MLK3 (D-11) - sc-166639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MLK3 (D-11): sc-166639. Western blot analysis of MLK3 expression in non-transfected: sc-110760 (A) and human MLK3 transfected: sc-111047 (B) 293 whole cell lysates.

MLK3 (H-3) - sc-166592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MLK3 (H-3): sc-166592. Western blot analysis of MLK3 expression in non-transfected: sc-110760 (A) and human MLK3 transfected: sc-111047 (B) 293 whole cell lysates.

MLK3 (H-300) - sc-13072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MLK3 (H-300): sc-13072. Western blot analysis of MLK3 expression in non-transfected 293: sc-110760 (A) and human MLK3 transfected 293: sc-111047 (B) whole cell lysates.

Anti-MLK3 (phospho T277 + S281) antibody - ab191530 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MLK3 (phospho T277 + S281) antibody (ab191530)Lane 1 : HEK293T whole cell lysateLane 2 : NIH 3T3 whole cell lysateLane 3 : PC12 whole cell lysate

Anti-MLK3 antibody - ab94526 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MLK3 antibody (ab94526) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MLK3 antibody [EP1460Y] - ab51068 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1460Y
Anti-MLK3 antibody [EP1460Y] (ab51068) at 1/5000 dilution + A431 cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution

Anti-MLK3 antibody - C-terminal - ab198844 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MLK3 antibody - C-terminal (ab198844) at 1/400 dilution + LO2 cell lysate at 40 µgdeveloped using the ECL technique

Anti-MAP3K11 / MLK3 Antibody (C-Terminus) - LS-C48412 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (C-Terminus) - LS-C16573 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (FITC) - LS-C207211 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (APC) - LS-C207210 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (AP) - LS-C207208 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (Biotin) - LS-C207209 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (Azide-free, HRP) - LS-C207212 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (PE) - LS-C207213 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (aa640-689) - LS-C199267 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using MLK3 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-MAP3K11 / MLK3 Antibody - LS-C322833 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (phospho-Thr277/Ser281) - LS-C342166 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K11 / MLK3 Antibody (aa719-768) - LS-C111894 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAP3K11 / MLK3 antibody LS-C111894 Western blot of HepG2 cell lysate.

Anti-MAP3K11 / MLK3 Antibody - LS-C163997 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of MAP3K11 Antibody in mouse lung tissue lysates (35 ug/lane). MAP3K11 (arrow) was detected using the purified antibody.
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