MAP3K11
| Gene Symbol | MAP3K11 |
|---|---|
| Entrez Gene | 4296 |
| Alt Symbol | MEKK11, MLK-3, MLK3, PTK1, SPRK |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase kinase 11 |
| Other Description | SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase |
| Swissprots | Q59F06 Q53H00 B4DS76 Q16584 Q6P2G4 |
| Accessions | CAI94235 EAW74417 EAW74418 Q16584 AB209655 BAD92892 AK057256 BAG51893 AK090614 BAG52196 AK092015 AK222781 BAD96501 AK299609 BAG61538 AK315557 BAG37933 AK316032 BAH14403 AU119082 BC011263 AAH11263 BC064543 AAH64543 L32976 AAA59859 U07747 AAA19647 XR_428915 NM_002419 NP_002410 |
| Function | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent. |
| Tissue Specificity | Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|PubMed:8195146}. |
| Top Pathways | MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD) |
MLK3 CRISPR/Cas9 KO Plasmid (h) - sc-401781 from Santa Cruz Biotechnology
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MLK3 HDR Plasmid (h) - sc-401781-HDR from Santa Cruz Biotechnology
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MLK3 Double Nickase Plasmid (h) - sc-401781-NIC from Santa Cruz Biotechnology
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MLK3 Double Nickase Plasmid (h2) - sc-401781-NIC-2 from Santa Cruz Biotechnology
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MLK3 CRISPR Activation Plasmid (h) - sc-401781-ACT from Santa Cruz Biotechnology
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MLK3 CRISPR Activation Plasmid (h2) - sc-401781-ACT-2 from Santa Cruz Biotechnology
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MLK3 Lentiviral Activation Particles (h) - sc-401781-LAC from Santa Cruz Biotechnology
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MLK3 Lentiviral Activation Particles (h2) - sc-401781-LAC-2 from Santa Cruz Biotechnology
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MLK3 siRNA (h) - sc-35945 from Santa Cruz Biotechnology
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MLK3 shRNA Plasmid (h) - sc-35945-SH from Santa Cruz Biotechnology
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MLK3 shRNA (h) Lentiviral Particles - sc-35945-V from Santa Cruz Biotechnology
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MLK3 RNAi - H00004296-R02 from Novus Biologicals
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MISSION® siRNA - SIHK1126 from Sigma-Aldrich
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MISSION® siRNA - SIHK1128 from Sigma-Aldrich
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MISSION® siRNA - SIHK1127 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12988 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12988 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04267 from Sigma-Aldrich
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MAP3K11 siRNA (Human) - CRH2914 from Cohesion Biosciences
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MLK3 CRISPR/Cas9 KO Plasmid (h2) - sc-401781-KO-2 from Santa Cruz Biotechnology
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MLK3 HDR Plasmid (h2) - sc-401781-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MAP3K11 (NM_002419.3) - SHH337631 from Creative biogene
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shRNA set against Human MAP3K11(NM_002419.3) - SHH173891 from Creative biogene
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Human MAP3K11 siRNA - orb263416 from Biorbyt
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MAP3K11 shRNA Plasmid (Human) - CHH2914 from Cohesion Biosciences
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