MAP3K11

Gene Symbol	MAP3K11
Entrez Gene	4296
Alt Symbol	MEKK11, MLK-3, MLK3, PTK1, SPRK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 11
Other Description	SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase
Swissprots	Q59F06 Q53H00 B4DS76 Q16584 Q6P2G4
Accessions	CAI94235 EAW74417 EAW74418 Q16584 AB209655 BAD92892 AK057256 BAG51893 AK090614 BAG52196 AK092015 AK222781 BAD96501 AK299609 BAG61538 AK315557 BAG37933 AK316032 BAH14403 AU119082 BC011263 AAH11263 BC064543 AAH64543 L32976 AAA59859 U07747 AAA19647 XR_428915 NM_002419 NP_002410
Function	Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
Tissue Specificity	Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|PubMed:8195146}.
Top Pathways	MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAP3K11 cDNA clone(NM_002419.3) - CDFH010978 from Creative Biomart Species Human Accession NM_002419.3

Human MAP3K11 cDNA clone(NM_002419.3) - CDFH010979 from Creative Biomart Species Human Accession NM_002419.3

Human MAP3K11 ORF Clone(NM_002419.3) - CDCR283155 from Creative Biomart Species Human Accession NM_002419.3

Human MAP3K11 ORF Clone(NM_002419.3) - CDCR283156 from Creative Biomart Species Human Accession NM_002419.3

Human MLK3 Gene ORF cDNA clone in cloning vector - HG11067-M from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-His tag - HG11067-NH from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11067-ANG from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11067-ACG from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-His tag - HG11067-CH from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11067-NF from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11067-NM from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11067-CF from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11067-CM from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11067-CY from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11067-NY from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid - HG11067-UT from Sino Biological Species Human

Human MLK3 ORF clone(NM_002419.3) - CDCL185358 from Creative biogene Species Human

Human MEKK11 Gene - orb91701 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human MAP3K11 cDNA Clone(NM_002419.3) - CDFH010978 from Creative biogene Species Human

Human MAP3K11 cDNA Clone(NM_002419.3) - CDFH010979 from Creative biogene Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11067-ACR from Sino Biological Species Human

Human MLK3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11067-ANR from Sino Biological Species Human

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