MAP3K11

Gene Symbol	MAP3K11
Entrez Gene	4296
Alt Symbol	MEKK11, MLK-3, MLK3, PTK1, SPRK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 11
Other Description	SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase
Swissprots	Q59F06 Q53H00 B4DS76 Q16584 Q6P2G4
Accessions	CAI94235 EAW74417 EAW74418 Q16584 AB209655 BAD92892 AK057256 BAG51893 AK090614 BAG52196 AK092015 AK222781 BAD96501 AK299609 BAG61538 AK315557 BAG37933 AK316032 BAH14403 AU119082 BC011263 AAH11263 BC064543 AAH64543 L32976 AAA59859 U07747 AAA19647 XR_428915 NM_002419 NP_002410
Function	Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
Tissue Specificity	Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|PubMed:8195146}.
Top Pathways	MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MLK3 protein fragment - ab125630 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human MLK3 protein fragment - ab158899 from Abcam Category Protein Source Wheat germ Species Human

Human MLK3 protein fragment - ab158900 from Abcam Category Protein Source Wheat germ Species Human

MAP3K11 / MLK3 Antibody Blocking Peptide - LS-E20442 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MLK3 Protein - H00004296-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MLK3 Protein - H00004296-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MLK3 Peptide - P2906 from Novus Biologicals Category Peptide Species Human

MLK3-Antibody-Center-Blocking-Peptide - BP7921c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP3K11 Blocking Peptide - 33R-7411 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MLK3 (phospho-Thr277/Ser281) Blocking Peptide - abx064174 from Abbexa Category Peptide Species Human, Mouse, Rat

MAP3K11 - H00004296-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP3K11 - H00004296-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP3K11 - H00004296-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

MAP3K11 - H00004296-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP3K11 - H00004296-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP3K11 - P5600 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MAP3K11 fusion protein - ag2636 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-Tagged - MAP3K11-1039H from Creative Biomart Category Protein Species Human

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-tagged - MAP3K11-1257H from Creative Biomart Category Protein Source Insect cells Species Human

MLK3 (pT277/S281) Blocking Peptide - CBP2980 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Mitogen-activated protein kinase kinase kinase 11(MAP3K11) ,pa - CSB-YP013419HU CSB-EP013419HU CSB-BP013419HU CSB-MP013419HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human MAP3K11/MLK3 His - CSI13425 from Cell Science Prices $615.00 Sizes 10 μg Species Human

MLK3-Antibody-C-term-Blocking-Peptide - BP7921a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP3K11 Peptide, Human - M34GP09167H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mitogen-activated protein kinase kinase kinase 11 (MAP3K11), partial, Recombinant Protein - MBS1320618 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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