| Gene Symbol |
MAP3K11
|
| Entrez Gene |
4296
|
| Alt Symbol |
MEKK11, MLK-3, MLK3, PTK1, SPRK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 11
|
| Other Description |
SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase
|
| Swissprots |
Q59F06 Q53H00 B4DS76 Q16584 Q6P2G4
|
| Accessions |
CAI94235 EAW74417 EAW74418 Q16584 AB209655 BAD92892 AK057256 BAG51893 AK090614 BAG52196 AK092015 AK222781 BAD96501 AK299609 BAG61538 AK315557 BAG37933 AK316032 BAH14403 AU119082 BC011263 AAH11263 BC064543 AAH64543 L32976 AAA59859 U07747 AAA19647 XR_428915 NM_002419 NP_002410
|
| Function |
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
|
| Tissue Specificity |
Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|PubMed:8195146}.
|
| Top Pathways |
MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD)
|
![Western Blot: MLK3 Overexpression Lysate (Adult Normal) [NBP2-10830] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MLK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2321_MLK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10830-img0001.jpg)