PKMYT1

Gene Symbol PKMYT1
Entrez Gene 9088
Alt Symbol MYT1, PPP1R126
Species Human
Gene Type protein-coding
Description protein kinase, membrane associated tyrosine/threonine 1
Other Description membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|myt1 kinase|protein phosphatase 1, regulatory subunit 126
Swissprots Q99640 F8W164 B4DXD4 O14731 Q8TCM9 I3L1V2 D3DUA4 B3KUN8 Q7LE24
Accessions AAC04477 AAC04478 AAN40703 EAW85439 EAW85440 Q99640 AK097642 BAG53500 AK098452 AK294379 BAG57637 AK301926 BAG63346 AK303005 BAG64138 AK309964 BC121161 AAI21162 BC121162 AAI21163 BC130011 AAI30012 BC153823 BC160025 AAI60025 BG530406 BQ017689 DB009060 DB111506 U56816 AAC50949 XM_011522734 XP_011521036 XM_011522735 XP_011521037 XM_011522736 XP_011521038 NM_001258450 NP_001245379 NM_001258451 NP_001245380 NM_004203 NP_004194 NM_182687 NP_872629
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
Top Pathways Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

Phospho-Myt1 (Ser83) Antibody - 4281 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT29 cells, untreated or nocodazole-treated (50ng/ml), using Phospho-Myt1 (Ser83) Antibody (upper) or Myt1 Antibody #4282 (lower).

Myt1 Antibody - 4282 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT29 cells, untreated (lane 1), nocodazole-treated (50 ng/ml, lane 2), or UV-treated (lane 3), using Myt1 Antibody.

Myt 1 (N-17) - sc-6353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Myt 1 (N-17): sc-6353. Western blot analysis of Myt 1 expression in HeLa (A) and K-562 (B) whole cell lysates.

Myt 1 (H-300) - sc-13081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Myt 1 (H-300): sc-13081. Western blot analysis of Myt 1 expression in HeLa (A), K-562 (B) and SK-BR-3 (C) whole cell lysates.

Myt 1 (C-20) - sc-6352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Myt1 (Ser 83) - sc-33402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MYT1 (H-147) - sc-367435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 antibody - ab200387 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling PKMYT1 with ab200387 at 1/50 dilution.

Anti-PKMYT1 antibody - ab166719 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKMYT1 antibody (ab166719) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate with synthesized peptide

Anti-PKMYT1 antibody - ab79367 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKMYT1 antibody (ab79367) at 1/500 dilutionLane 1 : HeLa cell extractsLane 2 : HeLa cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-PKMYT1 antibody [1C3] - ab117946 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C3
ab117946, at a 1/100 dilution, staining COS7 cells transiently transfected by pCMV6-ENTRY PKMYT1, by immunofluorescene.

Anti-PKMYT1 antibody [2B4] - ab114022 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B4
All lanes : Anti-PKMYT1 antibody [2B4] (ab114022) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with the pCMV6-ENTRY control Lane 2 : HEK293T cell lysare transfected with the pCMV6-ENTRY PKMYT1

Anti-PKMYT1 antibody [EPR1844(2)] - ab134108 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1844(2)
All lanes : Anti-PKMYT1 antibody [EPR1844(2)] (ab134108) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Anti-PKMYT1 antibody - N-terminal - ab166725 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKMYT1 antibody - N-terminal (ab166725) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-PKMYT1 Antibody (clone 5E1) - LS-C114939 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E1
IHC of paraffin-embedded endometrium tissue using anti-PKMYT1 mouse monoclonal antibody. (Dilution 1:50).

Anti-PKMYT1 Antibody (Internal, clone EPR1844(2)) - LS-C138098 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1844(2)
Western blot analysis on (A) K562, (B) HeLa, and (C) HepG2 cell lysates using anti-PKMYT1 antibody.

Anti-PKMYT1 Antibody (Thr495, Biotin) - LS-C279852 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (C-Terminus, PE) - LS-C279853 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (Thr495, FITC) - LS-C279854 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (Thr495, Azide-free, HRP) - LS-C279855 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (Thr495, PE) - LS-C279857 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (phospho-Thr495) - LS-C327968 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (phospho-Thr495) - LS-C327971 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (Thr495) - LS-C329866 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKMYT1 Antibody (aa113-143) - LS-C329977 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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