PKMYT1

Gene Symbol PKMYT1
Entrez Gene 9088
Alt Symbol MYT1, PPP1R126
Species Human
Gene Type protein-coding
Description protein kinase, membrane associated tyrosine/threonine 1
Other Description membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|myt1 kinase|protein phosphatase 1, regulatory subunit 126
Swissprots Q99640 F8W164 B4DXD4 O14731 Q8TCM9 I3L1V2 D3DUA4 B3KUN8 Q7LE24
Accessions AAC04477 AAC04478 AAN40703 EAW85439 EAW85440 Q99640 AK097642 BAG53500 AK098452 AK294379 BAG57637 AK301926 BAG63346 AK303005 BAG64138 AK309964 BC121161 AAI21162 BC121162 AAI21163 BC130011 AAI30012 BC153823 BC160025 AAI60025 BG530406 BQ017689 DB009060 DB111506 U56816 AAC50949 XM_011522734 XP_011521036 XM_011522735 XP_011521037 XM_011522736 XP_011521038 NM_001258450 NP_001245379 NM_001258451 NP_001245380 NM_004203 NP_004194 NM_182687 NP_872629
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
Top Pathways Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

PKMYT1-Over-expression-Lysate - LY10294a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PKMYT1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PKMYT1 gene

PKMYT1 293T Cell Transient Overexpression Lysate(Denatured) - H00009088-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

PKMYT1 293 Cell Lysate - 401240 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

PKMYT1 Overexpression Lysate (Denatured) - H00009088-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: PKMYT1 transfected lysate (54.5 KDa) Lane 2: Non-transfected lysate.

PKMYT1 Overexpression Lysate (Native) - NBL1-14463 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: PKMYT1 Overexpression Lysate (Adult Normal) [NBL1-14463] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PKMYT1.

PKMYT1 Over-expression Lysate Product - GWB-EE394B from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human PKMYT1 Knockdown Stable Cell Line - CSC-DC011849 from Creative biogene

Category Cell Line
Species Human
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