PKMYT1
| Gene Symbol | PKMYT1 |
|---|---|
| Entrez Gene | 9088 |
| Alt Symbol | MYT1, PPP1R126 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, membrane associated tyrosine/threonine 1 |
| Other Description | membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|myt1 kinase|protein phosphatase 1, regulatory subunit 126 |
| Swissprots | Q99640 F8W164 B4DXD4 O14731 Q8TCM9 I3L1V2 D3DUA4 B3KUN8 Q7LE24 |
| Accessions | AAC04477 AAC04478 AAN40703 EAW85439 EAW85440 Q99640 AK097642 BAG53500 AK098452 AK294379 BAG57637 AK301926 BAG63346 AK303005 BAG64138 AK309964 BC121161 AAI21162 BC121162 AAI21163 BC130011 AAI30012 BC153823 BC160025 AAI60025 BG530406 BQ017689 DB009060 DB111506 U56816 AAC50949 XM_011522734 XP_011521036 XM_011522735 XP_011521037 XM_011522736 XP_011521038 NM_001258450 NP_001245379 NM_001258451 NP_001245380 NM_004203 NP_004194 NM_182687 NP_872629 |
| Function | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. |
| Top Pathways | Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis |
Myt 1 CRISPR/Cas9 KO Plasmid (h) - sc-417203 from Santa Cruz Biotechnology
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Myt 1 HDR Plasmid (h) - sc-417203-HDR from Santa Cruz Biotechnology
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Myt 1 Double Nickase Plasmid (h) - sc-417203-NIC from Santa Cruz Biotechnology
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Myt 1 Double Nickase Plasmid (h2) - sc-417203-NIC-2 from Santa Cruz Biotechnology
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Myt 1 CRISPR Activation Plasmid (h) - sc-417203-ACT from Santa Cruz Biotechnology
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Myt 1 CRISPR Activation Plasmid (h2) - sc-417203-ACT-2 from Santa Cruz Biotechnology
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Myt 1 Lentiviral Activation Particles (h) - sc-417203-LAC from Santa Cruz Biotechnology
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Myt 1 Lentiviral Activation Particles (h2) - sc-417203-LAC-2 from Santa Cruz Biotechnology
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Myt 1 siRNA (h) - sc-35997 from Santa Cruz Biotechnology
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Myt 1 shRNA Plasmid (h) - sc-35997-SH from Santa Cruz Biotechnology
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Myt 1 shRNA (h) Lentiviral Particles - sc-35997-V from Santa Cruz Biotechnology
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Myt1 RNAi - H00004661-R01 from Novus Biologicals
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PKMYT1 RNAi - H00009088-R03 from Novus Biologicals
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PKMYT1 RNAi - H00009088-R04 from Novus Biologicals
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MISSION® esiRNA - EHU149711 from Sigma-Aldrich
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MISSION® siRNA - SIHK1730 from Sigma-Aldrich
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MISSION® siRNA - SIHK1731 from Sigma-Aldrich
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MISSION® siRNA - SIHK1729 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16870 from Sigma-Aldrich
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PKMYT1 siRNA (Human) - CRH6003 from Cohesion Biosciences
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shRNA set against Human PKMYT1 (NM_182687.2) - SHH376528 from Creative biogene
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Human PKMYT1 siRNA - orb266505 from Biorbyt
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PKMYT1 shRNA Plasmid (Human) - CHH6003 from Cohesion Biosciences
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PKMYT1 miRNA 3'UTR clone - MiUTR3H-05022 from Creative biogene
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