PKMYT1

Gene Symbol	PKMYT1
Entrez Gene	9088
Alt Symbol	MYT1, PPP1R126
Species	Human
Gene Type	protein-coding
Description	protein kinase, membrane associated tyrosine/threonine 1
Other Description	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|myt1 kinase|protein phosphatase 1, regulatory subunit 126
Swissprots	Q99640 F8W164 B4DXD4 O14731 Q8TCM9 I3L1V2 D3DUA4 B3KUN8 Q7LE24
Accessions	AAC04477 AAC04478 AAN40703 EAW85439 EAW85440 Q99640 AK097642 BAG53500 AK098452 AK294379 BAG57637 AK301926 BAG63346 AK303005 BAG64138 AK309964 BC121161 AAI21162 BC121162 AAI21163 BC130011 AAI30012 BC153823 BC160025 AAI60025 BG530406 BQ017689 DB009060 DB111506 U56816 AAC50949 XM_011522734 XP_011521036 XM_011522735 XP_011521037 XM_011522736 XP_011521038 NM_001258450 NP_001245379 NM_001258451 NP_001245380 NM_004203 NP_004194 NM_182687 NP_872629
Function	Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PKMYT1 full length protein - ab125565 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PKMYT1 protein fragment - ab160331 from Abcam Category Protein Source Wheat germ Species Human

MYT1 Antibody Blocking Peptide - LS-E4153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MYT1 Antibody Blocking Peptide - LS-E11496 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKMYT1 Antibody Blocking Peptide - LS-E2952 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKMYT1 Antibody Blocking Peptide - LS-E8754 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKMYT1 Antibody Blocking Peptide - LS-E7288 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PKMYT1 Protein - H00009088-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Myt1 Protein - H00004661-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PKMYT1 Peptide - P1358 from Novus Biologicals Category Peptide Species Human

Phospho-MYT1T495-Antibody-Blocking-peptide - BP3173a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

MYT1-PKMYT1-Antibody-C-term-Blocking-peptide - BP7196b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Myt1-T495-Non-phospho-Control-Peptide - SP2064c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-Myt1-T495-Phospho-Peptide - SP2064b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

Myt1-T495-Phospho-Peptide - SP2064a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

PKMYT1 - H00009088-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PKMYT1 - H00009088-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PKMYT1 - P5606 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

MYT1 fusion protein - Ag24580 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MYT1, GST-tagged - PKMYT1-7007H from Creative Biomart Category Protein Source Sf9 Cells Species Human

MYT1 protein-GST fusion - 009-001-S53 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

MYT1 protein-GST fusion - 009-001-S53S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhi - CSB-YP858720HU CSB-EP858720HU CSB-BP858720HU CSB-MP858720HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PKMYT1 (transcript variant 1) - TP322657 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MYT1 fusion protein - Ag24587 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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