TARBP2

Gene Symbol	TARBP2
Entrez Gene	6895
Alt Symbol	LOQS, TRBP, TRBP1, TRBP2
Species	Human
Gene Type	protein-coding
Description	TAR (HIV-1) RNA binding protein 2
Other Description	RISC-loading complex subunit TARBP2|TAR (HIV) RNA binding protein 2|TAR (HIV) RNA-binding protein 2|TAR (HIV) RNA-binding protein TRBP1|TAR RNA binding protein 2|TAR RNA-binding protein 2|trans-activation responsive RNA-binding protein|trans-activation-responsive RNA-binding protein
Swissprots	Q9BRY2 Q15633 Q8WY33 Q8WY32 Q12878
Accessions	AAL55730 AAL55731 EAW96717 EAW96718 EAW96719 EAW96720 Q15633 AK290737 BAF83426 AK293728 BAH11581 AK309569 BC002419 BC005860 AAH05860 BC150583 BI771121 BT007140 AAP35804 DQ893549 ABM84475 DQ893931 ABM84857 M60801 AAA36765 U08998 AAB50581 XM_005269114 XP_005269171 XM_005269115 XP_005269172 XM_005269116 XP_005269173 XM_005269117 XP_005269174 XM_005269120 XP_005269177 XM_005269122 XP_005269179 XM_006719581 XP_006719644 XM_011538712 XP_011537014 XR_944695 NM_004178 NP_004169 NM_134323 NP_599150 NM_134324 NP_599151
Function	Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269|PubMed:12475984, ECO:000
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RISC-loading complex subunit TARBP2 (TARBP2), Human, ELISA Kit - CSB-EL023127HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

RISC-loading complex subunit TARBP2, TARBP2, Human, ELISA Kit - E3425h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.312-20 ng/mL.

TARBP2 (Human) IP-WB Antibody Pair - H00006895-PW3 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TARBP2 (Human) IP-WB Antibody Pair - H00006895-PW4 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TARBP2 (Human) IP-WB Antibody Pair - H00006895-PW5 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TARBP2 (Human) Matched Antibody Pair - H00006895-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TAR (HIV-1) RNA binding protein 2, ELISA Kit - MBS924501 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TARBP2 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

Human RISC-loading complex subunit TARBP2(TARBP2) ELISA kit - CSB-EL023127HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Rat TARBP2 / TRBP2 ELISA Kit (Custom ELISA) - LS-F19884 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Bovine TARBP2 / TRBP2 ELISA Kit (Custom ELISA) - LS-F19882 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Mouse TARBP2 / TRBP2 ELISA Kit (Custom ELISA) - LS-F19883 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human RISC-loading complex subunit TARBP2 ELISA Kit - abx251623 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human TARBP2 / TRBP2 ELISA Kit (Sandwich ELISA) - LS-F13479 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Human RISC-loading complex subunit TARBP2 (TARBP2) ELISA Kit - EKC35415 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human RISC-loading complex subunit TARBP2 ELISA Kit - EKE54424 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.19 ng/mL Range 0.312-20 ng/mL.

TARBP2 - EKH4548 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

TARBP2 ELISA Kit (Human) (OKEH01711) - OKEH01711 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.19 ng/mL Range 0.312 - 20 ng/mL

Human TARBP2 ELISA Kit - E033843 from Biobool Category ELISA Kit Sensitivity <0.188ng/ml

Human RISC-loading complex subunit TARBP2 ELISA Kit - EK4595 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Range 0.31 ng/mL -20.0 ng/mL

Human RISC-loading complex subunit TARBP2 (TARBP2) ELISA Kit - AE16436HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

RISC-loading complex subunit TARBP2, ELISA Kit - MBS761402 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.312-20ng/ml

RISC-loading complex subunit TARBP2, ELISA Kit - MBS2881610 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL.

RISC-loading complex subunit TARBP2, ELISA Kit - MBS9428421 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 0.19ng/mL Range 0.312-20 ng/mL.

Human TARBP2 / TRBP2 ELISA Kit (Sandwich ELISA) - LS-F33619 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.312-20 ng/ml

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