TARBP2

Gene Symbol TARBP2
Entrez Gene 6895
Alt Symbol LOQS, TRBP, TRBP1, TRBP2
Species Human
Gene Type protein-coding
Description TAR (HIV-1) RNA binding protein 2
Other Description RISC-loading complex subunit TARBP2|TAR (HIV) RNA binding protein 2|TAR (HIV) RNA-binding protein 2|TAR (HIV) RNA-binding protein TRBP1|TAR RNA binding protein 2|TAR RNA-binding protein 2|trans-activation responsive RNA-binding protein|trans-activation-responsive RNA-binding protein
Swissprots Q9BRY2 Q15633 Q8WY33 Q8WY32 Q12878
Accessions AAL55730 AAL55731 EAW96717 EAW96718 EAW96719 EAW96720 Q15633 AK290737 BAF83426 AK293728 BAH11581 AK309569 BC002419 BC005860 AAH05860 BC150583 BI771121 BT007140 AAP35804 DQ893549 ABM84475 DQ893931 ABM84857 M60801 AAA36765 U08998 AAB50581 XM_005269114 XP_005269171 XM_005269115 XP_005269172 XM_005269116 XP_005269173 XM_005269117 XP_005269174 XM_005269120 XP_005269177 XM_005269122 XP_005269179 XM_006719581 XP_006719644 XM_011538712 XP_011537014 XR_944695 NM_004178 NP_004169 NM_134323 NP_599150 NM_134324 NP_599151
Function Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269|PubMed:12475984, ECO:000
Subcellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

TRBP2 (D-5) - sc-514124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRBP2 (D-5): sc-514124. Western blot analysis of TRBP2 expression in MCF7 (A), Hep G2 (B), HEK293T (C), HeLa (D) and NTERA-2 cl.D1 (E) whole cell lysates.

TRBP2 (C-18) - sc-27612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRBP2 (C-18): sc-27612. Western blot analysis of TRBP2 expression in MCF7 whole cell lysate.

TRBP2 (H-57) - sc-292550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRBP2 (H-57): sc-292550. Western blot analysis of TRBP2 expression in MCF7 whole cell lysate.

TRBP2 (E-25) - sc-134110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

TRBP2 (V-15) - sc-27615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRBP2 (V-15): sc-27615. Western blot analysis of TRBP2 expression in Hep G2 (A) and MCF7 (B) whole cell lysates.

Anti-TRBP antibody - ab157812 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRBP antibody (ab157812) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : A431 cell lysateLane 3 : K562 cell lysateLane 4 : HepG2 cell lysate

Anti-TRBP antibody - ab72547 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRBP antibody (ab72547) at 6 µg/mlLane 1 : human brain lysateLane 2 : human brain lysate with immunizing peptide

Anti-TRBP antibody [1D9] - ab129325 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1D9
ab129325, at 5 µg/ml, staining TRBP in formalin-fixed, paraffin-embedded Human prostate tissue by Immunohistochemistry.

Anti-TRBP antibody [EPR13550] - ab180947 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13550
Western blot analysis of HepG2 cell lysate immunoprecipitated with ab180947 at 1/40 dilution. Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated secondary antibody used at 1/1000 dilution.

Anti-TARBP2 / TRBP2 Antibody (aa25-74) - LS-C31734 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-TARBP2 / TRBP2 Antibody - LS-C62063 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TARBP2 / TRBP2 Antibody (clone 1G6) - LS-C139100 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G6
Western blot of TARBP2 expression in transfected 293T cell line by TARBP2 monoclonal antibody (M08), clone 1G6.

Anti-TARBP2 / TRBP2 Antibody (clone 2H1) - LS-C139079 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2H1
TARBP2 monoclonal antibody (M02), clone 2H1. Western blot of TARBP2 expression in Jurkat.

Anti-TARBP2 / TRBP2 Antibody (aa38-68, AP) - LS-C207719 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (clone 2G10) IHC-plus™ - LS-B6386 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2G10
Anti-TARBP2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6386 concentration 5 ug/ml.

Anti-TARBP2 / TRBP2 Antibody (aa38-68, Biotin) - LS-C207721 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-68, APC) - LS-C207720 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-68, Azide-free, HRP) - LS-C207722 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-68, FITC) - LS-C207723 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-68, PE) - LS-C207726 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa141-251, Azide-free) - LS-C328943 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-68) - LS-C330206 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa38-281) - LS-C179142 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TARBP2 / TRBP2 Antibody (aa340-390) - LS-C47380 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of normal human brain using control (rabbit Ig) at 5 ug/ml.

Anti-TARBP2 / TRBP2 Antibody - LS-C334509 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of K562 cell line, using TARBP2 antibody.
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