TARBP2

Gene Symbol	TARBP2
Entrez Gene	6895
Alt Symbol	LOQS, TRBP, TRBP1, TRBP2
Species	Human
Gene Type	protein-coding
Description	TAR (HIV-1) RNA binding protein 2
Other Description	RISC-loading complex subunit TARBP2|TAR (HIV) RNA binding protein 2|TAR (HIV) RNA-binding protein 2|TAR (HIV) RNA-binding protein TRBP1|TAR RNA binding protein 2|TAR RNA-binding protein 2|trans-activation responsive RNA-binding protein|trans-activation-responsive RNA-binding protein
Swissprots	Q9BRY2 Q15633 Q8WY33 Q8WY32 Q12878
Accessions	AAL55730 AAL55731 EAW96717 EAW96718 EAW96719 EAW96720 Q15633 AK290737 BAF83426 AK293728 BAH11581 AK309569 BC002419 BC005860 AAH05860 BC150583 BI771121 BT007140 AAP35804 DQ893549 ABM84475 DQ893931 ABM84857 M60801 AAA36765 U08998 AAB50581 XM_005269114 XP_005269171 XM_005269115 XP_005269172 XM_005269116 XP_005269173 XM_005269117 XP_005269174 XM_005269120 XP_005269177 XM_005269122 XP_005269179 XM_006719581 XP_006719644 XM_011538712 XP_011537014 XR_944695 NM_004178 NP_004169 NM_134323 NP_599150 NM_134324 NP_599151
Function	Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269|PubMed:12475984, ECO:000
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRBP full length protein - ab181920 from Abcam Category Protein Source E. coli Species Human

TARBP2 / TRBP2 Antibody Blocking Peptide - LS-E2977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TARBP2 / TRBP2 Antibody Blocking Peptide - LS-E14794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRBP Recombinant Protein - H00006895-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

TRBP Recombinant Protein - H00006895-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TARBP2-Antibody-N-term-Blocking-peptide - BP14108a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TARBP2 Blocking Peptide - 33R-1405 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TARBP2 protein (His tag) - 80R-3835 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

TARBP2 (1-345, ) - AR51522PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

TARBP2 (1-345, ) - AR51522PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

TARBP2 - H00006895-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

TARBP2 - H00006895-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TARBP2 - H00006895-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TARBP2, 1-345aa, Human, E.coli - 01-P2702 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

TRBP fusion protein - Ag8255 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TRBP fusion protein - Ag8269 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TARBP2 - TARBP2-209H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TARBP2, GST-tagged - TARBP2-8473H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human TARBP2, GST-tagged - TARBP2-8421H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human TARBP2, His-tagged - TARBP2-8654H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TARBP2, His-tagged - TARBP2-8483H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRBP, GST-tagged - TRBP-3399H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RISC-loading complex subunit TARBP2(TARBP2) - CSB-YP623007HU CSB-EP623007HU CSB-BP623007HU CSB-MP623007HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TARBP2, 1-345aa, Human, E.coli (Denatured) - ATGP2702 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

TARBP2 Protein - abx163407 from Abbexa Category Protein Species Human, Mouse, Rat

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