TARBP2
| Gene Symbol | TARBP2 |
|---|---|
| Entrez Gene | 6895 |
| Alt Symbol | LOQS, TRBP, TRBP1, TRBP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAR (HIV-1) RNA binding protein 2 |
| Other Description | RISC-loading complex subunit TARBP2|TAR (HIV) RNA binding protein 2|TAR (HIV) RNA-binding protein 2|TAR (HIV) RNA-binding protein TRBP1|TAR RNA binding protein 2|TAR RNA-binding protein 2|trans-activation responsive RNA-binding protein|trans-activation-responsive RNA-binding protein |
| Swissprots | Q9BRY2 Q15633 Q8WY33 Q8WY32 Q12878 |
| Accessions | AAL55730 AAL55731 EAW96717 EAW96718 EAW96719 EAW96720 Q15633 AK290737 BAF83426 AK293728 BAH11581 AK309569 BC002419 BC005860 AAH05860 BC150583 BI771121 BT007140 AAP35804 DQ893549 ABM84475 DQ893931 ABM84857 M60801 AAA36765 U08998 AAB50581 XM_005269114 XP_005269171 XM_005269115 XP_005269172 XM_005269116 XP_005269173 XM_005269117 XP_005269174 XM_005269120 XP_005269177 XM_005269122 XP_005269179 XM_006719581 XP_006719644 XM_011538712 XP_011537014 XR_944695 NM_004178 NP_004169 NM_134323 NP_599150 NM_134324 NP_599151 |
| Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269|PubMed:12475984, ECO:000 |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. |
TRBP2 CRISPR/Cas9 KO Plasmid (h) - sc-402488 from Santa Cruz Biotechnology
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TRBP2 HDR Plasmid (h) - sc-402488-HDR from Santa Cruz Biotechnology
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TRBP2 Double Nickase Plasmid (h) - sc-402488-NIC from Santa Cruz Biotechnology
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TRBP2 Double Nickase Plasmid (h2) - sc-402488-NIC-2 from Santa Cruz Biotechnology
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TRBP2 CRISPR Activation Plasmid (h) - sc-402488-ACT from Santa Cruz Biotechnology
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TRBP2 CRISPR Activation Plasmid (h2) - sc-402488-ACT-2 from Santa Cruz Biotechnology
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TRBP2 Lentiviral Activation Particles (h) - sc-402488-LAC from Santa Cruz Biotechnology
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TRBP2 Lentiviral Activation Particles (h2) - sc-402488-LAC-2 from Santa Cruz Biotechnology
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TRBP2 siRNA (h) - sc-106846 from Santa Cruz Biotechnology
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TRBP2 shRNA Plasmid (h) - sc-106846-SH from Santa Cruz Biotechnology
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TRBP2 shRNA (h) Lentiviral Particles - sc-106846-V from Santa Cruz Biotechnology
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TRBP RNAi - H00006895-R01V from Novus Biologicals
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TRBP RNAi - H00006895-R02 from Novus Biologicals
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MISSION® esiRNA - EHU154801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21003 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21003 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01691 from Sigma-Aldrich
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TARBP2 siRNA (Human) - CRH4722 from Cohesion Biosciences
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TRBP RNAi - H00006895-R01 from Novus Biologicals
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TRBP RNAi - H00006895-R03 from Novus Biologicals
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TARBP2 - MBS8231052 from MyBioSource
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shRNA set against Human TARBP2 (NM_004178.4) - SHH423080 from Creative biogene
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shRNA set against Human TARBP2(NM_134323.1) - SHL056441 from Creative biogene
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shRNA set against Human TARBP2(NM_004178.4) - SHL056458 from Creative biogene
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shRNA set against Rat Tars(NM_001006976.1) - SHL056476 from Creative biogene
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