BABAM1

Gene Symbol BABAM1
Entrez Gene 29086
Alt Symbol C19orf62, HSPC142, MERIT40, NBA1
Species Human
Gene Type protein-coding
Description BRISC and BRCA1 A complex member 1
Other Description BRCA1-A complex subunit MERIT40|BRISC and BRCA1-A complex member 1|mediator of RAP80 interactions and targeting subunit of 40 kDa|mediator of Rap80 interactions and targeting 40 kDa|new component of the BRCA1 A complex|new component of the BRCA1-A complex|new component of the BRCAA1 A complex
Swissprots Q9P018 Q6FIA0 B4DRY9 B4DVR1 A8MQT0 Q9NWV8
Accessions EAW84584 EAW84585 Q9NWV8 AF161491 AAF29106 AI948445 AJ572521 AK000578 BAA91268 AK025970 AK225047 AK301193 BAG62773 AK308590 AL136692 CAB66627 AM393637 CAL38513 AM393724 CAL38600 BC000788 AAH00788 BC006244 AAH06244 BC091491 AAH91491 BP246573 CR533526 CAG38557 CX866662 NM_001033549 NP_001028721 NM_001288756 NP_001275685 NM_001288757 NP_001275686 NM_014173 NP_054892
Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Subcellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

Phospho-MERIT40 (Ser29) Antibody - 12110 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A-431 cells, untreated (-) or treated with λ phosphatase and calf intestinal phosphatase (CIP) (+), using Phospho-MERIT40 (Ser29) Antibody (upper) or MERIT40 Antibody #9500 (lower).

MERIT40 Antibody - 9500 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MERIT40 Antibody.

MERIT40 (D7Y5K) Rabbit mAb - 12711 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7Y5K
Western blot analysis of extracts from various cell lines using MERIT40 (D7Y5K) Rabbit mAb.

C19orf62 (H-10) - sc-398570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C19orf62 (H-10): sc-398570. Western blot analysis of C19orf62 expression in non-transfected: sc-117752 (A) and human C19orf62 transfected: sc-128160 (B) 293T whole cell lysates.

C19orf62 (H-45) - sc-367917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
C19orf62 (H-45): sc-367917. Western blot analysis of C19orf62 expression in non-transfected: sc-117752 (A) and human C19orf62 transfected: sc-128160 (B) 293T whole cell lysates.

C19orf62 (K-14) - sc-160989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C19orf62 (S-12) - sc-160990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C19orf62 (S-12): sc-160990. Western blot analysis of C19orf62 expression in KNRK (A), HeLa (B) and COLO 320DM (C) whole cell lysates.

Anti-HSPC142 antibody - ab167202 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-HSPC142 antibody (ab167202) at 1 µg/mlLane 1 : Lysate of 293T cells transfected with HSPC142Lane 2 : Lysate of 293T cells (non-transfected)Lysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilution

Anti-HSPC142 antibody - ab115017 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling HSPC142 with ab115017 at 1/1000 (1µg/ml). Detection: DAB.

Anti-HSPC142 antibody - ab115040 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of HSPC142 by Western Blot of Immunprecipitates. ab115040 at 1µg/ml staining HSPC142 in HeLa whole cell lysate immunoprecipitated using ab115040 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded). Detection: Chemiluminescence with exposure time of 10 seconds.

Anti-HSPC142 antibody - ab124647 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab124647, at 1/250 dilution, staining HSPC142 in formalin-fixed, paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry with DAB staining.

Anti-HSPC142 antibody - ab37592 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-HSPC142 antibody [GT1251] - ab184197 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT1251
All lanes : Anti-HSPC142 antibody [GT1251] (ab184197) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HSPC142 antibody [GT2810] - ab184528 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT2810
Immunofluorescent analysis of paraformaldehyde fixed HeLa cells labeling HSPC142 using ab184528 at a 1/500 dilution. Counterstain Hoechst 33342.

Anti-BABAM1 / HSPC142 Antibody (aa36-85) IHC-plus™ - LS-B8224 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BABAM1 / HSPC142 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8224 dilution 5-7.5 ug/ml.

Anti-BABAM1 / HSPC142 Antibody (aa182-329) - LS-C184781 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, AP) - LS-C258955 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, APC) - LS-C258957 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, Biotin) - LS-C258959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, FITC) - LS-C258960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, Azide-free, HRP) - LS-C258961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa9-37, PE) - LS-C258962 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa1-50) - LS-C289249 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody - LS-C308346 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BABAM1 / HSPC142 Antibody (aa16-45) - LS-C322123 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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