| Gene Symbol |
BABAM1
|
| Entrez Gene |
29086
|
| Alt Symbol |
C19orf62, HSPC142, MERIT40, NBA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BRISC and BRCA1 A complex member 1
|
| Other Description |
BRCA1-A complex subunit MERIT40|BRISC and BRCA1-A complex member 1|mediator of RAP80 interactions and targeting subunit of 40 kDa|mediator of Rap80 interactions and targeting 40 kDa|new component of the BRCA1 A complex|new component of the BRCA1-A complex|new component of the BRCAA1 A complex
|
| Swissprots |
Q9P018 Q6FIA0 B4DRY9 B4DVR1 A8MQT0 Q9NWV8
|
| Accessions |
EAW84584 EAW84585 Q9NWV8 AF161491 AAF29106 AI948445 AJ572521 AK000578 BAA91268 AK025970 AK225047 AK301193 BAG62773 AK308590 AL136692 CAB66627 AM393637 CAL38513 AM393724 CAL38600 BC000788 AAH00788 BC006244 AAH06244 BC091491 AAH91491 BP246573 CR533526 CAG38557 CX866662 NM_001033549 NP_001028721 NM_001288756 NP_001275685 NM_001288757 NP_001275686 NM_014173 NP_054892
|
| Function |
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
|