LAMTOR2

Gene Symbol LAMTOR2
Entrez Gene 28956
Alt Symbol ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Other Description MAPBP-interacting protein|MAPKSP1 adaptor protein|endosomal adaptor protein p14|late endosomal/lysosomal Mp1-interacting protein|late endosomal/lysosomal adaptor and MAPK and MTOR activator 2|mitogen-activated protein-binding protein-interacting protein (MAPBPIP)|ragulator complex protein LAMTOR2|roadblock domain containing 3|roadblock domain-containing protein 3
Swissprots Q5VY99 Q5VY97 Q9Y2Q5 Q5VY98
Accessions EAW53004 Q9Y2Q5 AF070659 AAD20965 AK307086 BC024190 AAH24190 BM353842 BU184679 CA438137 DB566869 DQ892965 ABM83891 DQ896212 ABM87211 NM_001145264 NP_001138736 NM_014017 NP_054736
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

LAMTOR2/ROBLD3 (D7C10) Rabbit mAb - 8145 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7C10
Western blot analysis of extracts from various cell lines using LAMTOR2/ROBLD3 (D7C10) Rabbit mAb.

MAPBPIP (FL-125) - sc-135300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MAPBPIP (Y-13) - sc-161827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-robld3 antibody - ab191576 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-robld3 antibody (ab191576) at 1 µg/ml + HepG2 cell lysate at 15 µg

Anti-robld3 antibody - ab129252 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-robld3 antibody (ab129252) at 1/100 dilution + HL-60 cell line lysates at 35 µg

Anti-robld3 antibody [EPR14378] - ab183514 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14378
Immunohistochemical analysis of paraffin-embedded Human gastric carcinoma labeling robld3 using ab183514 at a 1/50 dilution, using a HRP Polymer for Rabbit IgG secondary antibody and counterstained with Hematoxylin.

Anti-LAMTOR2 Antibody (aa41-70, AP) - LS-C268436 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70, APC) - LS-C268437 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70, PE) - LS-C268442 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70, Azide-free, HRP) - LS-C268441 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70, Biotin) - LS-C268439 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70, FITC) - LS-C268440 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa40-70) - LS-C324758 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMTOR2 Antibody (aa41-70) - LS-C162674 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ROBLD3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-LAMTOR2 Antibody (Internal) - LS-C336138 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of LAMTOR2 in human spleen tissue with LAMTOR2 antibody at 5 ug/mL.

ROBLD3 Antibody - NBP1-71687 from Novus Biologicals

Prices $279.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ROBLD3 Antibody [NBP1-71687] - ROBLD3 Antibody was tested at 1:100 in NIH/3T3 cells with FITC (green). Nuclei (Blue) were counterstained with DAPI (blue).

ROBLD3 Antibody - NBP1-87951 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ROBLD3 Antibody [NBP1-87951] - Analysis in control (vector only transfected HEK293T lysate) and lAMTOR2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

ROBLD3 Polyclonal Antibody - bs-13705R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13705R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13705R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13705R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13705R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, Cy3 Conjugated - bs-13705R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, Cy5 Conjugated - bs-13705R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ROBLD3 Polyclonal Antibody, Cy5.5 Conjugated - bs-13705R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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