| Gene Symbol |
LAMTOR2
|
| Entrez Gene |
28956
|
| Alt Symbol |
ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
|
| Other Description |
MAPBP-interacting protein|MAPKSP1 adaptor protein|endosomal adaptor protein p14|late endosomal/lysosomal Mp1-interacting protein|late endosomal/lysosomal adaptor and MAPK and MTOR activator 2|mitogen-activated protein-binding protein-interacting protein (MAPBPIP)|ragulator complex protein LAMTOR2|roadblock domain containing 3|roadblock domain-containing protein 3
|
| Swissprots |
Q5VY99 Q5VY97 Q9Y2Q5 Q5VY98
|
| Accessions |
EAW53004 Q9Y2Q5 AF070659 AAD20965 AK307086 BC024190 AAH24190 BM353842 BU184679 CA438137 DB566869 DQ892965 ABM83891 DQ896212 ABM87211 NM_001145264 NP_001138736 NM_014017 NP_054736
|
| Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
|
| Subcellular Location |
Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|