LAMTOR2

Gene Symbol LAMTOR2
Entrez Gene 28956
Alt Symbol ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Other Description MAPBP-interacting protein|MAPKSP1 adaptor protein|endosomal adaptor protein p14|late endosomal/lysosomal Mp1-interacting protein|late endosomal/lysosomal adaptor and MAPK and MTOR activator 2|mitogen-activated protein-binding protein-interacting protein (MAPBPIP)|ragulator complex protein LAMTOR2|roadblock domain containing 3|roadblock domain-containing protein 3
Swissprots Q5VY99 Q5VY97 Q9Y2Q5 Q5VY98
Accessions EAW53004 Q9Y2Q5 AF070659 AAD20965 AK307086 BC024190 AAH24190 BM353842 BU184679 CA438137 DB566869 DQ892965 ABM83891 DQ896212 ABM87211 NM_001145264 NP_001138736 NM_014017 NP_054736
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

MAPBPIP CRISPR/Cas9 KO Plasmid (h) - sc-409901 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP HDR Plasmid (h) - sc-409901-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP Double Nickase Plasmid (h) - sc-409901-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP Double Nickase Plasmid (h2) - sc-409901-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP CRISPR Activation Plasmid (h) - sc-409901-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP CRISPR Activation Plasmid (h2) - sc-409901-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP Lentiviral Activation Particles (h) - sc-409901-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP Lentiviral Activation Particles (h2) - sc-409901-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAPBPIP siRNA (h) - sc-88091 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAPBPIP shRNA Plasmid (h) - sc-88091-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAPBPIP shRNA (h) Lentiviral Particles - sc-88091-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU027171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18493 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18493 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LAMTOR2 siRNA (Human) - CRH9125 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LAMTOR2 (NM_014017.3) - SHH328379 from Creative biogene

Category siRNA
Species Reactivities Human

Human LAMTOR2 siRNA - orb269627 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LAMTOR2 shRNA Plasmid (Human) - CHH9125 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LAMTOR2 miRNA 3'UTR clone - MiUTR4H-TG07615 from Creative biogene

Species Reactivities Human
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