LAMTOR2

Gene Symbol	LAMTOR2
Entrez Gene	28956
Alt Symbol	ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Other Description	MAPBP-interacting protein|MAPKSP1 adaptor protein|endosomal adaptor protein p14|late endosomal/lysosomal Mp1-interacting protein|late endosomal/lysosomal adaptor and MAPK and MTOR activator 2|mitogen-activated protein-binding protein-interacting protein (MAPBPIP)|ragulator complex protein LAMTOR2|roadblock domain containing 3|roadblock domain-containing protein 3
Swissprots	Q5VY99 Q5VY97 Q9Y2Q5 Q5VY98
Accessions	EAW53004 Q9Y2Q5 AF070659 AAD20965 AK307086 BC024190 AAH24190 BM353842 BU184679 CA438137 DB566869 DQ892965 ABM83891 DQ896212 ABM87211 NM_001145264 NP_001138736 NM_014017 NP_054736
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human robld3 full length protein - ab156748 from Abcam Category Protein Source E. coli Species Human

Human robld3 full length protein - ab101637 from Abcam Category Protein Source E. coli Species Human

LAMTOR2 Antibody Blocking Peptide - LS-E2369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ROBLD3 Protein - NBP2-23179 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human ROBLD3 Protein - NBP1-50918 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

ROBLD3 Recombinant Protein - P3418 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Human

ROBLD3-Antibody-Center-Blocking-peptide - BP13338c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ROBLD3 Protein (OPPA02619) - OPPA02619 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human LAMTOR2 protein - orb191093 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human ROBLD3 protein - orb169205 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E. coli Species Human

Human LAMTOR2 His tag protein - orb84584 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

LAMTOR2 protein (His tag) - 80R-2772 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

ROBLD3 protein (His tag) - 80R-1595 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

ROBLD3 (1-125, His-tag) - AR09774PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

ROBLD3 (1-125, His-tag) - AR09774PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

ROBLD3 (1-125, His-tag) - AR50891PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

ROBLD3 (1-125, His-tag) - AR50891PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

ROBLD3 - P3418 from Acris Antibodies Category Protein Prices $580.00 Sizes 100 µg Species Human

Roadblock Domain Containing 3, Human Recombinant - 228-12771-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Roadblock Domain Containing 3 - 228-12771-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Roadblock Domain Containing 3 - 228-12771-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

LAMTOR2, 1-125aa, Human His tag, E.coli - 01-P2067 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

ROBLD3, 1-125aa, Human, His tag, E.coli - 01-2312-3 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

LAMTOR2 Peptide - 7711P from ProSci Category Peptide Species Human

ROBLD3 fusion protein - Ag19089 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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