LAMTOR2

Gene Symbol	LAMTOR2
Entrez Gene	28956
Alt Symbol	ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Other Description	MAPBP-interacting protein|MAPKSP1 adaptor protein|endosomal adaptor protein p14|late endosomal/lysosomal Mp1-interacting protein|late endosomal/lysosomal adaptor and MAPK and MTOR activator 2|mitogen-activated protein-binding protein-interacting protein (MAPBPIP)|ragulator complex protein LAMTOR2|roadblock domain containing 3|roadblock domain-containing protein 3
Swissprots	Q5VY99 Q5VY97 Q9Y2Q5 Q5VY98
Accessions	EAW53004 Q9Y2Q5 AF070659 AAD20965 AK307086 BC024190 AAH24190 BM353842 BU184679 CA438137 DB566869 DQ892965 ABM83891 DQ896212 ABM87211 NM_001145264 NP_001138736 NM_014017 NP_054736
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ROBLD3-Over-expression-Lysate - LY15685a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

LAMTOR2 overexpression lysate - LY415522 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ROBLD3 293 Cell Lysate - 407314 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ROBLD3 Overexpression Lysate (Native) - NBL1-12864 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ROBLD3 Over-expression Lysate Product - GWB-3A3C94 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human LAMTOR2 Knockdown Stable Cell Line - CSC-DC008536 from Creative biogene Category Cell Line Species Human

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