Gene Symbol | ALKBH1 |
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Entrez Gene | 8846 |
Alt Symbol | ABH, ABH1, ALKBH, alkB, hABH |
Species | Human |
Gene Type | protein-coding |
Description | alkB, alkylation repair homolog 1 (E. coli) |
Other Description | DNA lyase ABH1|DNA oxidative demethylase ALKBH1|alkylated DNA repair protein alkB homolog 1|alkylation repair, alkB homolog|alpha-ketoglutarate-dependent dioxygenase ABH1 |
Swissprots | Q9ULA7 Q13686 Q8TAU1 |
Accessions | AAF01478 EAW81300 EAW81301 EAW81302 Q13686 BC015024 AAH15024 BC025787 AAH25787 BX537699 DQ890543 ABM92160 DQ893703 ABM84629 X91992 CAA63047 XM_005268165 XP_005268222 NM_006020 NP_006011 NM_001039506 |
Function | Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. |
ALKB (C-20) - sc-48121 from Santa Cruz Biotechnology
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ALKB (F-4) - sc-374301 from Santa Cruz Biotechnology
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ALKB (H-300) - sc-67186 from Santa Cruz Biotechnology
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Anti-ABH1 antibody - ab169689 from Abcam
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Anti-ABH1 antibody - ab113507 from Abcam
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Anti-ABH1 antibody - ab97589 from Abcam
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Anti-ABH1 antibody - ab88775 from Abcam
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Anti-ABH1 antibody [EPR6175(2)] - ab128895 from Abcam
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Anti-ABH1 antibody [EPR6176] - ab126596 from Abcam
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Anti-ABH1 antibody [hABH1-151] - ab49738 from Abcam
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Anti-ABH1 antibody - N-terminal - ab166726 from Abcam
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Anti-ALKBH1 / ALKB Antibody (aa8-216) - LS-C178535 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody - LS-C341990 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (aa97-146) - LS-C145568 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (aa166-387) - LS-C186395 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody - LS-C334580 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (aa1-245, clone 1B8) - LS-C339690 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (Internal, clone EPR6176) - LS-C152279 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (aa1-245, clone 4C4) - LS-C339667 from LifeSpan Bioscience
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Anti-ALKBH1 / ALKB Antibody (N-Terminus, clone EPR6175(2)) - LS-C152427 from LifeSpan Bioscience
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ABH1 Antibody - NBP2-14283 from Novus Biologicals
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ABH1 Antibody - NBP1-79909 from Novus Biologicals
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ABH1 Antibody - H00008846-B02 from Novus Biologicals
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ABH1 Antibody - H00008846-B01P from Novus Biologicals
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ABH1/ALKB Polyclonal Antibody - bs-12565R from Bioss
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