| Gene Symbol |
ALKBH1
|
| Entrez Gene |
8846
|
| Alt Symbol |
ABH, ABH1, ALKBH, alkB, hABH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkB, alkylation repair homolog 1 (E. coli)
|
| Other Description |
DNA lyase ABH1|DNA oxidative demethylase ALKBH1|alkylated DNA repair protein alkB homolog 1|alkylation repair, alkB homolog|alpha-ketoglutarate-dependent dioxygenase ABH1
|
| Swissprots |
Q9ULA7 Q13686 Q8TAU1
|
| Accessions |
AAF01478 EAW81300 EAW81301 EAW81302 Q13686 BC015024 AAH15024 BC025787 AAH25787 BX537699 DQ890543 ABM92160 DQ893703 ABM84629 X91992 CAA63047 XM_005268165 XP_005268222 NM_006020 NP_006011 NM_001039506
|
| Function |
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}.
|