ALKBH1

Gene Symbol	ALKBH1
Entrez Gene	8846
Alt Symbol	ABH, ABH1, ALKBH, alkB, hABH
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 1 (E. coli)
Other Description	DNA lyase ABH1|DNA oxidative demethylase ALKBH1|alkylated DNA repair protein alkB homolog 1|alkylation repair, alkB homolog|alpha-ketoglutarate-dependent dioxygenase ABH1
Swissprots	Q9ULA7 Q13686 Q8TAU1
Accessions	AAF01478 EAW81300 EAW81301 EAW81302 Q13686 BC015024 AAH15024 BC025787 AAH25787 BX537699 DQ890543 ABM92160 DQ893703 ABM84629 X91992 CAA63047 XM_005268165 XP_005268222 NM_006020 NP_006011 NM_001039506
Function	Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ABH1 protein (His-DHFR tag) - ab127495 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Human ABH1 full length protein - ab132191 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ABH1 peptide - ab19826 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ALKBH1 / ALKB Antibody Blocking Peptide - LS-E22576 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ABH1 Protein - H00008846-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ALKBH1 Blocking Peptide - 33R-10376 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALKBH1 fusion protein - ag17548 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ALKBH1 fusion protein - ag4027 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Alkylated DNA repair protein alkB homolog 1(ALKBH1) - CSB-YP614439HU CSB-EP614439HU CSB-BP614439HU CSB-MP614439HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Alkylated DNA repair protein alkB homolog 1 (ALKBH1) - MBS1395268 from MyBioSource Category Protein Prices $1,855.00, $1,855.00, $2,320.00, $2,320.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ALKBH1 - TP306529 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ABH1 Recombinant Protein Antigen - NBP2-14283PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALKBH1-Antibody-C-term-Blocking-peptide - BP5867b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALKBH1 Peptide, Human - M34GP00511H from Creative Peptides Category Peptide Source Synthetic. Species Human

ALKBH1 fusion protein - Ag27471 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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