ALKBH1

Gene Symbol	ALKBH1
Entrez Gene	8846
Alt Symbol	ABH, ABH1, ALKBH, alkB, hABH
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 1 (E. coli)
Other Description	DNA lyase ABH1|DNA oxidative demethylase ALKBH1|alkylated DNA repair protein alkB homolog 1|alkylation repair, alkB homolog|alpha-ketoglutarate-dependent dioxygenase ABH1
Swissprots	Q9ULA7 Q13686 Q8TAU1
Accessions	AAF01478 EAW81300 EAW81301 EAW81302 Q13686 BC015024 AAH15024 BC025787 AAH25787 BX537699 DQ890543 ABM92160 DQ893703 ABM84629 X91992 CAA63047 XM_005268165 XP_005268222 NM_006020 NP_006011 NM_001039506
Function	Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ALKBH1-Over-expression-Lysate - LY14969a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ALKBH1 293T Cell Transient Overexpression Lysate(Denatured) - H00008846-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ALKBH Lysate(Denatured) - H00008846-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ALKBH1 293 Cell Lysate - 401626 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

ABH1 Overexpression Lysate (Denatured) - H00008846-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ABH1 Overexpression Lysate (Denatured) - H00008846-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

ABH1 Overexpression Lysate (Native) - NBL1-07472 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ALKBH1 Over-expression Lysate Product - GWB-939C84 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human ALKBH1 Knockdown Stable Cell Line - CSC-DC000511 from Creative biogene Category Cell Line Species Human

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