ALKBH1

Gene Symbol ALKBH1
Entrez Gene 8846
Alt Symbol ABH, ABH1, ALKBH, alkB, hABH
Species Human
Gene Type protein-coding
Description alkB, alkylation repair homolog 1 (E. coli)
Other Description DNA lyase ABH1|DNA oxidative demethylase ALKBH1|alkylated DNA repair protein alkB homolog 1|alkylation repair, alkB homolog|alpha-ketoglutarate-dependent dioxygenase ABH1
Swissprots Q9ULA7 Q13686 Q8TAU1
Accessions AAF01478 EAW81300 EAW81301 EAW81302 Q13686 BC015024 AAH15024 BC025787 AAH25787 BX537699 DQ890543 ABM92160 DQ893703 ABM84629 X91992 CAA63047 XM_005268165 XP_005268222 NM_006020 NP_006011 NM_001039506
Function Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}.

ALKB CRISPR/Cas9 KO Plasmid (h) - sc-408412 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB HDR Plasmid (h) - sc-408412-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB Double Nickase Plasmid (h) - sc-408412-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB Double Nickase Plasmid (h2) - sc-408412-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB CRISPR Activation Plasmid (h) - sc-408412-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB CRISPR Activation Plasmid (h2) - sc-408412-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB Lentiviral Activation Particles (h) - sc-408412-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB Lentiviral Activation Particles (h2) - sc-408412-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKB siRNA (h) - sc-60153 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKB shRNA Plasmid (h) - sc-60153-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKB shRNA (h) Lentiviral Particles - sc-60153-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU135521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3066 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3066 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09518 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09518

ALKBH1 siRNA (Human) - CRH5841 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH1 - MBS8217842 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ALKBH1 (NM_006020.2) - SHH235214 from Creative biogene

Category siRNA
Species Reactivities Human

Human ALKBH1 siRNA - orb266343 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH1 shRNA Plasmid (Human) - CHH5841 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALKBH1 miRNA 3'UTR clone - MiUTR1H-00306 from Creative biogene

Species Reactivities Human
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