| Gene Symbol |
AKAP5
|
| Entrez Gene |
9495
|
| Alt Symbol |
AKAP75, AKAP79, H21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
A kinase (PRKA) anchor protein 5
|
| Other Description |
A-kinase anchor protein 5|A-kinase anchor protein 79 kDa|A-kinase anchoring protein 75/79|AKAP 79|cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
|
| Swissprots |
P24588 A2RRB8
|
| Accessions |
EAW80862 P24588 AK124004 AK315336 BAG37736 BC057229 AAH57229 BC131516 AAI31517 DA942424 M90359 AAA58363 NM_004857 NP_004848
|
| Function |
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:21771783}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Note=Associates with lipid rafts.
|
| Tissue Specificity |
Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
|
![Western Blot: AKAP5 Overexpression Lysate (Adult Normal) [NBL1-07429] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AKAP5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11997_AKAP5%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07429-img0002.jpg)