| Gene Symbol | AKAP5 |
|---|---|
| Entrez Gene | 9495 |
| Alt Symbol | AKAP75, AKAP79, H21 |
| Species | Human |
| Gene Type | protein-coding |
| Description | A kinase (PRKA) anchor protein 5 |
| Other Description | A-kinase anchor protein 5|A-kinase anchor protein 79 kDa|A-kinase anchoring protein 75/79|AKAP 79|cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein |
| Swissprots | P24588 A2RRB8 |
| Accessions | EAW80862 P24588 AK124004 AK315336 BAG37736 BC057229 AAH57229 BC131516 AAI31517 DA942424 M90359 AAA58363 NM_004857 NP_004848 |
| Function | May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:21771783}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Note=Associates with lipid rafts. |
| Tissue Specificity | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. |