Gene Symbol | AKAP5 |
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Entrez Gene | 9495 |
Alt Symbol | AKAP75, AKAP79, H21 |
Species | Human |
Gene Type | protein-coding |
Description | A kinase (PRKA) anchor protein 5 |
Other Description | A-kinase anchor protein 5|A-kinase anchor protein 79 kDa|A-kinase anchoring protein 75/79|AKAP 79|cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein |
Swissprots | P24588 A2RRB8 |
Accessions | EAW80862 P24588 AK124004 AK315336 BAG37736 BC057229 AAH57229 BC131516 AAI31517 DA942424 M90359 AAA58363 NM_004857 NP_004848 |
Function | May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. |
Subcellular Location | Membrane {ECO:0000269|PubMed:21771783}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Note=Associates with lipid rafts. |
Tissue Specificity | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. |
AKAP 79 CRISPR/Cas9 KO Plasmid (h) - sc-402647 from Santa Cruz Biotechnology
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AKAP 79 HDR Plasmid (h) - sc-402647-HDR from Santa Cruz Biotechnology
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AKAP 79 Double Nickase Plasmid (h) - sc-402647-NIC from Santa Cruz Biotechnology
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AKAP 79 Double Nickase Plasmid (h2) - sc-402647-NIC-2 from Santa Cruz Biotechnology
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AKAP 79 CRISPR Activation Plasmid (h) - sc-402647-ACT from Santa Cruz Biotechnology
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AKAP 79 CRISPR Activation Plasmid (h2) - sc-402647-ACT-2 from Santa Cruz Biotechnology
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AKAP 79 Lentiviral Activation Particles (h) - sc-402647-LAC from Santa Cruz Biotechnology
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AKAP 79 Lentiviral Activation Particles (h2) - sc-402647-LAC-2 from Santa Cruz Biotechnology
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AKAP 79 siRNA (h) - sc-29660 from Santa Cruz Biotechnology
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AKAP 79 shRNA Plasmid (h) - sc-29660-SH from Santa Cruz Biotechnology
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AKAP 79 shRNA (h) Lentiviral Particles - sc-29660-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3011 from Sigma-Aldrich
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AKAP5 siRNA (Human) - CRH6304 from Cohesion Biosciences
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AKAP5 - MBS8232200 from MyBioSource
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AKAP 79 CRISPR/Cas9 KO Plasmid (h2) - sc-402647-KO-2 from Santa Cruz Biotechnology
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AKAP 79 HDR Plasmid (h2) - sc-402647-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human AKAP5 (NM_004857.3) - SHH234286 from Creative biogene
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Human AKAP5 siRNA - orb266806 from Biorbyt
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AKAP5 shRNA Plasmid (Human) - CHH6304 from Cohesion Biosciences
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AKAP5 miRNA 3'UTR clone - MiUTR1H-00271 from Creative biogene
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