PKN1

Gene Symbol	PKN1
Entrez Gene	5585
Alt Symbol	DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Species	Human
Gene Type	protein-coding
Description	protein kinase N1
Other Description	protease-activated kinase 1|protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|protein kinase PKN-alpha|protein-kinase C-related kinase 1|serine-threonine kinase N|serine-threonine protein kinase N|serine/threonine protein kinase N|serine/threonine-protein kinase N1
Swissprots	Q15143 B3KVN3 A8K7W5 Q504U4 Q9UD44 Q16512 B2R9R4 Q8IUV5
Accessions	EAW84419 EAW84420 EAW84421 Q16512 AK123007 BAG53845 AK292130 BAF84819 AK313886 BAG36611 BC018575 BC040061 AAH40061 BC094766 AAH94766 BQ946818 BU628889 D26181 BAA05169 DQ892477 ABM83403 S75546 AAB33345 U33053 AAC50209 XM_011528128 XP_011526430 XM_011528129 XP_011526431 NM_002741 NP_002732 NM_213560 NP_998725
Function	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159',
Subcellular Location	Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Tissue Specificity	Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Top Pathways	Salmonella infection, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PRK1 Kinase Assay Kit - 7615 from Cell Signaling Technology Category Assay Kit

Human PKN1 ELISA Kit (Sandwich ELISA) - LS-F9452 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313-20 ng/ml

Protein Kinase N1, PKN1, Human, ELISA Kit - E-EL-H1187 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Kinase N1 (PKN1), Human, ELISA Kit - SEA501Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

Protein Kinase N1, PKN1, Mouse, ELISA Kit - E-EL-M0985 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase N1, PKN1, Rat, ELISA Kit - E-EL-R0821 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase N1, PKN1, Rabbit, ELISA Kit - E-EL-RB0540 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase N1, PKN1, Chicken, ELISA Kit - E-EL-Ch0231 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Protein Kinase N1, PKN1, Porcine, ELISA Kit - E-EL-P1461 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase N1, PKN1, Monkey, ELISA Kit - E-EL-MK2035 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PKN1 (Human) IP-WB Antibody Pair - H00005585-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

PKN1 (Human) IP-WB Antibody Pair - H00005585-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

PKN1 (Human) Matched Antibody Pair - H00005585-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human PKN1 ELISA Kit - HP0125 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PKN1 ELISA Kit - AP0125 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Human PKN1(Protein Kinase N1) ELISA Kit - E-EL-H1187 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

PKN1, ELISA Kit - MBS2512414 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKN1, ELISA Kit - MBS2503719 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKN1, ELISA Kit - MBS2507627 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKN1, ELISA Kit - MBS2502263 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

PKN1, ELISA Kit - MBS2508722 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKN1, ELISA Kit - MBS2504894 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKN1, ELISA Kit - MBS2506456 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

Protein Kinase N1, ELISA Kit - MBS027403 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase N1, ELISA Kit - MBS746252 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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