PKN1

Gene Symbol PKN1
Entrez Gene 5585
Alt Symbol DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Species Human
Gene Type protein-coding
Description protein kinase N1
Other Description protease-activated kinase 1|protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|protein kinase PKN-alpha|protein-kinase C-related kinase 1|serine-threonine kinase N|serine-threonine protein kinase N|serine/threonine protein kinase N|serine/threonine-protein kinase N1
Swissprots Q15143 B3KVN3 A8K7W5 Q504U4 Q9UD44 Q16512 B2R9R4 Q8IUV5
Accessions EAW84419 EAW84420 EAW84421 Q16512 AK123007 BAG53845 AK292130 BAF84819 AK313886 BAG36611 BC018575 BC040061 AAH40061 BC094766 AAH94766 BQ946818 BU628889 D26181 BAA05169 DQ892477 ABM83403 S75546 AAB33345 U33053 AAC50209 XM_011528128 XP_011526430 XM_011528129 XP_011526431 NM_002741 NP_002732 NM_213560 NP_998725
Function PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159',
Subcellular Location Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Tissue Specificity Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Top Pathways Salmonella infection, PI3K-Akt signaling pathway

Human PKN1 full length protein - ab159206 from Abcam

Category Protein
Source Wheat germ
Species Human
ab159206 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human PKN1 protein fragment - ab159207 from Abcam

Category Protein
Source Wheat germ
Species Human
ab159207 on a 12.5% SDS-PAGE stained with Coomassie Blue.

PAK1 Antibody Blocking Peptide - LS-E7347 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PAK1 Antibody Blocking Peptide - LS-E7369 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PAK1 Antibody Blocking Peptide - LS-E26147 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PAK1 Antibody Blocking Peptide - LS-E9372 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PKN1 Recombinant Protein - H00005585-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human PAK1 Protein - H00005058-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human PAK1 Protein - H00005058-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

PKN1 Partial Recombinant Protein - H00005585-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human PKN1 Protein - P4768 from Novus Biologicals

Category Protein
Prices $1,559.00
Sizes 100 µg
Source Insect
Species Human

PAK1 Recombinant Protein - P4740 from Novus Biologicals

Category Protein
Prices $1,559.00
Sizes 100 µg
Species Human

PAK1 Peptide - P1481 from Novus Biologicals

Category Peptide
Species Human

PAK1 Peptide - P1549 from Novus Biologicals

Category Peptide
Species Human

PAK1 Peptide - P2911 from Novus Biologicals

Category Peptide
Species Human

Goat anti PAK1 antibody Immunizing peptide - orb15827 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg
Species Human, Mouse, Rat

Human Protein Kinase N1 Protein - abx068758 from Abbexa

Category Protein
Source E.coli
Species Human

PKN1 Blocking Peptide - abx063131 from Abbexa

Category Peptide
Species Human, Mouse, Bovine, Monkey

PKN1 - H00005585-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

PKN1 - H00005585-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

PKN1 - H00005585-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

PKN1 - H00005585-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

PKN1 - P4768 from Acris Antibodies

Category Protein
Prices $1,380.00
Sizes 100 µg
Species Human

PKN1 - P5795 from Acris Antibodies

Category Protein
Prices $840.00
Sizes 5 µg
Species Human

PKN1 fusion protein - Ag5086 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human
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