| Gene Symbol |
PKN1
|
| Entrez Gene |
5585
|
| Alt Symbol |
DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase N1
|
| Other Description |
protease-activated kinase 1|protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|protein kinase PKN-alpha|protein-kinase C-related kinase 1|serine-threonine kinase N|serine-threonine protein kinase N|serine/threonine protein kinase N|serine/threonine-protein kinase N1
|
| Swissprots |
Q15143 B3KVN3 A8K7W5 Q504U4 Q9UD44 Q16512 B2R9R4 Q8IUV5
|
| Accessions |
EAW84419 EAW84420 EAW84421 Q16512 AK123007 BAG53845 AK292130 BAF84819 AK313886 BAG36611 BC018575 BC040061 AAH40061 BC094766 AAH94766 BQ946818 BU628889 D26181 BAA05169 DQ892477 ABM83403 S75546 AAB33345 U33053 AAC50209 XM_011528128 XP_011526430 XM_011528129 XP_011526431 NM_002741 NP_002732 NM_213560 NP_998725
|
| Function |
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159',
|
| Subcellular Location |
Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
|
| Tissue Specificity |
Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
|
| Top Pathways |
Salmonella infection, PI3K-Akt signaling pathway
|
