PKN1

Gene Symbol	PKN1
Entrez Gene	5585
Alt Symbol	DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Species	Human
Gene Type	protein-coding
Description	protein kinase N1
Other Description	protease-activated kinase 1|protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|protein kinase PKN-alpha|protein-kinase C-related kinase 1|serine-threonine kinase N|serine-threonine protein kinase N|serine/threonine protein kinase N|serine/threonine-protein kinase N1
Swissprots	Q15143 B3KVN3 A8K7W5 Q504U4 Q9UD44 Q16512 B2R9R4 Q8IUV5
Accessions	EAW84419 EAW84420 EAW84421 Q16512 AK123007 BAG53845 AK292130 BAF84819 AK313886 BAG36611 BC018575 BC040061 AAH40061 BC094766 AAH94766 BQ946818 BU628889 D26181 BAA05169 DQ892477 ABM83403 S75546 AAB33345 U33053 AAC50209 XM_011528128 XP_011526430 XM_011528129 XP_011526431 NM_002741 NP_002732 NM_213560 NP_998725
Function	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159',
Subcellular Location	Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Tissue Specificity	Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Top Pathways	Salmonella infection, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PKN CRISPR/Cas9 KO Plasmid (h) - sc-402299 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN HDR Plasmid (h) - sc-402299-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN Double Nickase Plasmid (h) - sc-402299-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN Double Nickase Plasmid (h2) - sc-402299-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN CRISPR Activation Plasmid (h) - sc-402299-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN CRISPR Activation Plasmid (h2) - sc-402299-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN Lentiviral Activation Particles (h) - sc-402299-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN Lentiviral Activation Particles (h2) - sc-402299-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKN siRNA (h) - sc-36261 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKN shRNA Plasmid (h) - sc-36261-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKN shRNA (h) Lentiviral Particles - sc-36261-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKN1 RNAi - H00005585-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PKN1 RNAi - H00005585-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PAK1 RNAi - H00005058-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU124131 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1732 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1733 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1734 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16871 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16871 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PKN1 siRNA (Human) - CRH3755 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKN1 RNAi - H00005585-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Human PKN1 siRNA - orb264257 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKN1 shRNA Plasmid (Human) - CHH3755 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

Search more