| Gene Symbol |
PAK6
|
| Entrez Gene |
56924
|
| Alt Symbol |
PAK5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
p21 protein (Cdc42/Rac)-activated kinase 6
|
| Other Description |
p21(CDKN1A)-activated kinase 6|serine/threonine-protein kinase PAK 6
|
| Swissprots |
G5E9R2 B3KYB0 A8K2G2 Q9NQU5
|
| Accessions |
CAC39969 CAK32184 CBX51397 EAW92395 EAW92396 EAW92397 EAW92398 EAW92399 EAW92400 EAW92401 Q9NQU5 AF276893 AAF82800 AJ236915 CAC18720 AK026592 AK131522 BAG54772 AK290227 BAF82916 AK315813 BAF98704 AK315817 BAF98708 BC035596 AAH35596 DA191028 DA229537 DA414215 DQ892109 ABM83035 DQ895303 ABM86229 HY128655 NM_001128628 NP_001122100 NM_001128629 NP_001122101 NM_001276717 NP_001263646 NM_001276718 NP_001263647 NM_020168 NP_064553
|
| Function |
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
|
| Tissue Specificity |
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
|
| Top Pathways |
Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway
|