PAK6

Gene Symbol	PAK6
Entrez Gene	56924
Alt Symbol	PAK5
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 6
Other Description	p21(CDKN1A)-activated kinase 6|serine/threonine-protein kinase PAK 6
Swissprots	G5E9R2 B3KYB0 A8K2G2 Q9NQU5
Accessions	CAC39969 CAK32184 CBX51397 EAW92395 EAW92396 EAW92397 EAW92398 EAW92399 EAW92400 EAW92401 Q9NQU5 AF276893 AAF82800 AJ236915 CAC18720 AK026592 AK131522 BAG54772 AK290227 BAF82916 AK315813 BAF98704 AK315817 BAF98708 BC035596 AAH35596 DA191028 DA229537 DA414215 DQ892109 ABM83035 DQ895303 ABM86229 HY128655 NM_001128628 NP_001122100 NM_001128629 NP_001122101 NM_001276717 NP_001263646 NM_001276718 NP_001263647 NM_020168 NP_064553
Function	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Subcellular Location	Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity	Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PAK6-cDNA-Clone - DC06899 from Abgent, a WuXi AppTec company Prices $919.35 Sizes 10 µg Species Human Accession BC035596

PAK6 - MBS1269516 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC035596

Human PAK6 cDNA clone(NM_001128628.1) - CDFH013647 from Creative Biomart Species Human Accession NM_001128628.1

Human PAK6 cDNA clone(NM_001128629.1) - CDFH013648 from Creative Biomart Species Human Accession NM_001128629.1

Human PAK6 ORF clone(NM_001128628.1) - CDCL185603 from Creative Biomart Species Human Accession NM_001128628.1

Human PAK6 ORF Clone(NM_001128628.1) - CDCR349100 from Creative Biomart Species Human Accession NM_001128628.1

Human PAK6 ORF Clone(NM_001128628.1) - CDCR349101 from Creative Biomart Species Human Accession NM_001128628.1

Human PAK6 ORF Clone(NM_001128629.1) - CDCR349102 from Creative Biomart Species Human Accession NM_001128629.1

Human PAK6 ORF Clone(NM_001128629.1) - CDCR349104 from Creative Biomart Species Human Accession NM_001128629.1

Human PAK6 Gene ORF cDNA clone in cloning vector - HG10803-M from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10803-ACR from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10803-ANR from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid - HG10803-UT from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10803-ACG from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10803-ANG from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10803-NF from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10803-NM from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10803-CF from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10803-CY from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-His tag - HG10803-NH from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10803-CM from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10803-NY from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-His tag - HG10803-CH from Sino Biological Species Human

Human PAK6 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10803-M-F from Sino Biological Species Human

Human PAK6 ORF clone(NM_001128628.1) - CDCL185603 from Creative biogene Species Human

Search more